Development and regulation of IL-17 producing cells during inflammation

The immune system has evolved to protect mammals from environmental stress factors such as pathogens. It functions as a fine-tuned consortium of effector units and suppressors. However, under certain pathologic conditions effector units may escape control and start to attack their own body. This leads to the development of autoimmune diseases, such as multiple sclerosis (MS). We use molecular and genetic tools such as Cre-recombinase and Cre/loxP, microscopy, next generation sequencing (including single cell sequencing and ATAC-seq), proteomics, and high dimensional flow cytometry to study the cellular and molecular mechanisms of MS pathology.

Research website

Positions held

  • Since 2011: W3 Univ. Prof. and Director, Institute for Molecular Medicine, University Medical Center (UMC), Mainz
  • 2010 - 2011: Acting Director, Institute for Molecular Medicine, University Medical Center (UMC), Mainz
  • 2005 - 2010: W2 Univ. Prof. in the I. Medical Department, University Medical Center (UMC), Mainz
  • 2001 - 2005: Independent Group Leader, Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne
  • 2000 - 2001: Research Associate, Department of Immunology, Institute for Genetics, University of Cologne
  • 1996 - 2000: Post-Doctoral fellow, Department of Immunology, Institute for Genetics, University of Cologne
  • 1994 - 1996: Post-Doctoral fellow, Department of Immunology, The Weizmann Institute of Science, Rehovot

Education

  • 1986 - 1990: Ph.D. with E. Mozes, Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot
  • 1986 - 1988: M.Sc. with Y. Aloni and O. Laub, Department of Genetics, The Weizmann Institute of Science, Rehovot
  • 1983 - 1986: B.Sc. Faculty of Life Sciences, Tel-Aviv University

Selected publications by Ari Waisman

Regen T, Isaac S, De Oliveira Amorim A, Gonzalo Núñez N, Hauptmann J, Shanmugavadivu A, Klein M, Sankowski R, Mufazalov IA, Yogev N, Huppert J, Wanke F, Witting M, Grill A, Galvez EJC, Nikolaev A, Blanfeld M, Prinz I, Schmitt-Kopplin P, Strowig T, Reinhardt C, Prinz M, Bopp T, Becher B, Ubeda C, Waisman A (2021) IL-17 controls the central nervous system autoimmunity through the intestinal microbiome. Science Immunology, 6(56):eaaz6563 Link

Hauptmann J, Johann L, Marini F, Kitic M, Colombo E, Mufazalov IA, Krueger M, Karram K, Moos S, Wanke F, Kurschus FC, Klein M, Cardoso S, Strauß J, Bolisetty S, Lühder F, Schwaninger M, Binder H, Bechman I, Bopp T, Agarwal A, Soares MP, Regen T, Waisman A (2020) Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier. Acta Neuropathol, 140(4):549-567 Link

Waisman A, Ebering A (2019) Unraveling the T-B tangle in anti-CD20 multiple sclerosis therapyProc Natl Acad Sci U S A, 116(51):25376-25377 Link

Kitic M, See P, Bruttger J, Ginhoux F, Waisman A (2019) Novel Microglia Depletion Systems: A Genetic Approach Utilizing Conditional Diphtheria Toxin Receptor Expression and a Pharmacological Model Based on the Blocking of Macrophage Colony-Stimulating Factor 1 ReceptorMethods Mol Biol, 2034:217-230 Link

Wanke F, Tang Y, Gronke K, Klebow S, Moos S, Hauptmann J, Shanmugavadivu A, Regen T, Mufazalov IA, Gabriel LA, Reißig S, Diefenbach A, Kurschus FC, Waisman A (2018) Expression of IL-17F is associated with non-pathogenic Th17 cellsJ Mol Med (Berl), 96:819–829 Link