Infection Immunology

Infectious diseases caused by viruses, bacteria, fungi or parasites still represent a key global health problem, aggravated by the increasing number of multi-resistent pathogens. In order to develop appropriate therapies and vaccination strategies, it is therefore of enormous importance to better understand the basic mechanisms underlying the various infectious diseases. 
In our group we are investigating several key aspects of infection biology. This includes a better understanding of host-pathogen interactions and the mechanisms that activate and regulate the infection-induced immune response. In addition, we explore the genetic background and the molecular processes of infection-associated immune responses and, most importantly, we search for novel ways of modulating the immune response, which finally aims to translate the findings of this basic research into clinical applications.

Positions held

2018 (Dec.) to date     W3-Professor and Director, JGU Mainz, Med. Microbiology & Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz

2008  – 2018 (Dec)    W3-Professor of Infection Immunology, Director, Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research / Hannover Medical School (MHH)    

2015 -2018    Guest Professor Microbiology and Infection Immunology, Facultad de Medicina, Universidad Católica de Cordoba, Argentina    

2010 - 2015    Head of Medical Microbiology Clinic, MVZ UroMik, Salzgitter Bad 

2002 - 2008    Group leader and specialization in Medical Microbiology (Residency), Institute f. Medical Microbiology, Immunology & Hygiene, Technical University Munich

1999-2002    Howard Hughes Medical Institute (HHMI) Postdoctoral Fellow, Skirball Institute of Biomolecular Medicine, NY University Medical Center, New York

1997-1999    Postdoctoral Fellow and Residency, Institute f. Med. Microbiology, Immunology & Hygiene, TU Munich     

1996-1997    Internship (“AiP”) and Postdoctoral Fellow, Institute f. Med. Microbiology, Immunology & Hygiene, TU Munich    

Education

2008    Board Approval Fellow in Clinical Microbiology and Infection Epidemiology
Habilitation, Institute f. Med. Microbiology, Immunol.& Hygiene, TU Munich 
    
1997    
Approbation as a doctor of human medicine
 
1996    MD in Medicine with Prof. Dr. med. S. Bhakdi, JGU Mainz  
 
1994 –1995    
Studies of Human Medicine, Ludwig-Maximilian-University Munich

1989 –1994    Studies of Human Medicine, Johannes Gutenberg University Mainz

Selected publications by Tim Sparwasser

Carriche, G.M., L. Almeida, P. Stuve, L. Velasquez, A. Dhillon-LaBrooy, U. Roy, M. Lindenberg, T. Strowig, C. Plaza-Sirvent, I. Schmitz, M. Lochner, A.K. Simon, and T. Sparwasser. 2020. Regulating T cell differentiation through the polyamine spermidine. J Allergy Clin Immunol

Mamareli, P., F. Kruse, C.W. Lu, M. Guderian, S. Floess, K. Rox, D.S.J. Allan, J.R. Carlyle, M. Bronstrup, R. Muller, L. Berod, T. Sparwasser*, and M. Lochner*. 2020. Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection. Mucosal Immunol.*equal contribution

Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stuve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Bronstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T*, and Berod L*. 2018. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab 28:504-515 e507.*equal contribution

Berod, L., C. Friedrich, A. Nandan, J. Freitag, S. Hagemann, K. Harmrolfs, A. Sandouk, C. Hesse, C.N. Castro, H. Bahre, S.K. Tschirner, N. Gorinski, M. Gohmert, C.T. Mayer, J. Huehn, E. Ponimaskin, W.R. Abraham, R. Muller, M. Lochner, and T. Sparwasser. 2014. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 20:1327-1333.

Pace, L., A. Tempez, C. Arnold-Schrauf, F. Lemaitre, P. Bousso, L. Fetler, T. Sparwasser, and S. Amigorena. 2012. Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science 338:532-536.

Research website