Ageing & Disease

Age-associated diseases (e.g. cancer, diabetes, neurodegenerative and autoimmune diseases) are some of the biggest killers facing modern society. The primary cause of ageing is loss of cell function due to DNA damage, epigenetic dysregulation, and protein mis-folding. We study each of these three mechanisms to determine their roles in ageing and disease. By doing this, we hope to find new ways to prevent diseases or even slow ageing.

Keywords: Telomeres, histone modifications, DNA methylation, proteostasis, mutation, DNA repair, immune system, autoimmunity, neurodegeneration, metabolic disease, cancer

Key techniques used: CRISPR-CAS9, embryonic stem cell culture, 3D organoid assays, flow cytometry, next-generation sequencing, bioinformatics, chromatin immunoprecipitation (ChIP)

IPP Groups in Ageing & Disease:

Andreas Daiber

The role of DNA damage in the pathogenesis of nitrate tolerance

Ari Waisman

Development and regulation of IL-17 producing cells during inflammation

Claudia Keller-Valsecchi

Gene dosage and developmental plasticity

Eva-Maria Krämer-Albers

Extracellular vesicles in cell communication

Julian König

Genomic views of protein-RNA interactions and splicing regulation

Katja Luck

Integrative Systems Biology

Leszek Wojnowski

Epigenetics of drug disposition and response

Marianne B. Müller

Deciphering the molecular basis of rapid antidepressant action

Marie-Luise Winz

Co-translational quality control in eukaryotic cells

Marion Silies

Gene regulatory mechanisms underlying neuronal function

Michael Kühn

Deciphering chromatin-based oncogenic mechanisms in NPM1 leukemia

Natalia Soshnikova

Intestinal stem cell biology in homeostasis and cancer

Soojin Ryu

Molecular mechanism for stress regulation using zebrafish

Susanne Strand

Epigenetic regulation of liver disease and cancer

Thomas Hankeln

Globins in the nucleus

Thomas Kindler

Role of oncogenic signalling in epigenetics and DNA repair

Tim Sparwasser

Infection Immunology

Uwe Wolfrum

Ciliary protein function: roles in DNA damage repair and gene regulation

Wolfram Ruf

Coagulation signaling in innate immunity