Dormann Lab
Research Publications Group Members Biography2025
Wagner K*, Keiten-Schmitz J*, Adhikari B, Patra U, Husnjak K, McNicoll F, Dormann D, Müller-McNicoll M, Tascher G, Wolf E and Müller S (2025) Induced proximity to PML protects TDP-43 from aggregation via SUMO-ubiquitin networks. Nat Chem Biol, doi: 10.1038/s41589-025-01886-4 (*indicates joint contribution) Link
Zhou Q, Sagmeister T, Hutten S, Bourgeois B, Pavkov-Keller T, Dormann D and Madl T (2025) Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3. Nat Commun, 16:4456 Link
Zippo E, Dormann D, Speck T and Stelzl LS (2025) Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates. Nat Commun, 16:4649 Link
2024
Arnold B, Kessler L, Okuda EK, Riegger RJ, Hernández Cañás MC, Zebrowska E, Bakisoglu C, Nagasse HY, Stanek D, Dormann D, Zarnack K, Heilemann M and Müller-McNicoll M (2024) Rapid depletion and super-resolution microscopy reveal an unexpected role of the nuclear-speckle protein SRSF5 in paraspeckle assembly and dynamics during cellular stress. bioRxiv, doi: 10.1101/2024.08.11.607506 Link
Dormann D# and Lemke EA# (2024) Adding intrinsically disordered proteins to biological ageing clocks. Nat Cell Biol, 26:851–858 (#indicates joint correspondence) Link
Hutten S, Chen JX, Isaacs AM and Dormann D (2024) Poly-GR impairs PRMT1-mediated arginine methylation of disease-linked RNA-binding proteins by acting as a substrate sink. Biochemistry, 63:2141–2152 Link
Niedner-Boblenz A, Monecke T, Hennig J, Klostermann M, Hofweber M, Davydova E, Gerber AP, Anosova I, Mayer W, Müller M, Heym RG, Janowski R, Paillart JC, Dormann D, Zarnack K, Sattler M and Niessing D (2024) Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation. Nucleic Acids Res, doi: 10.1093/nar/gkae1107 Link
Picchiarelli G, Wienand A, Megat S, Aly A, Been M, Mishra N, Hutten S, Sternburg E, Cauchy P, Dieterle S, Catinozzi M, Demais V, Tzeplaeff L, Huebers A, Zeuschner D, Rosenbohm A, Ludolph AC, Boutillier AL, Boeckers T, Dormann D, Demestre M, Sellier C, Lagier-Tourenne C, Storkebaum E and Dupuis L (2024) FUS controls muscle differentiation and structure through LLPS mediated recruitment of MEF2 and ETV5. bioRxiv, doi: 10.1101/2024.09.18.613669 Link
Proske M*, Janowski R*, Bacher S, Kang HS, Monecke T, Koehler T, Hutten S, Tretter J, Crois A, Molitor L, Varela-Rial A, Fino R, Donati E, De Fabritiis G, Dormann D, Sattler M and Niessing D (2024) PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association. Elife, 13:RP93561 (*indicates joint contribution) Link
2023
Critcher M, Gruijs da Silva LA, Dormann D, Campbell ZT, Le TK, Rocchi P and Sorgenfrei M (2023) Creating overview and summary figures. Trends Biochem Sci, 48:97–99 Link
Gruijs da Silva LA and Dormann D (2023) Sedimentation assays to assess the impact of posttranslational modifications on phase separation of RNA-binding proteins in vitro and in cells. Methods Mol Biol, 2563:325-339 Link
Riemenschneider H, Simonetti F*, Sheth U*, Katona E*, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D and Edbauer D (2023) Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo. Acta Neuropathol Commun, 11:112 (*indicates joint contribution) Link
Zibold J*, Lessard LER*, Picard F*, Gruijs da Silva L*, Zadorozhna Y*, Streichenberger N, Belotti E, Osseni A, Emerit A, Errazuriz-Cerda E, Michel-Calemard L, Menassa R, Coudert L, Wiessner M, Stucka R, Klopstock T, Simonetti F, Hutten S, Nonaka T, Hasegawa M, Strom TM, Bernard E, Ollagnon E, Urtizberea A, Dormann D, Petiot P, Schaeffer L#, Senderek J*# and Leblanc P*# (2023) The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis. Brain, 147:1768–1783 (*indicates joint contribution, #indicates joint correspondence) Link
2022
Dormann D and Behrends C (2022) Only solid waste, please! Mol Cell, 82:1408–1410 Link
Gruijs da Silva LA and Dormann D (2022) Sedimentation assays to assess the impact of posttranslational modifications on phase separation of RNA-binding proteins in vitro and in cells. Methods Mol Biol, 2563:325–339 Link
Gruijs da Silva LA, Simonetti F, Hutten S, Riemenschneider H, Sternburg EL, Pietrek LM, Gebel J, Dötsch V, Edbauer D, Hummer G, Stelzl LS and Dormann D (2022) Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation. EMBO J, 41:e108443 Link
Hutten S and Dormann D (2022) Hormone-inducible transport reporter assay to study nuclear import defects in neurodegenerative diseases. Methods Mol Biol, 2502:81-90 Link
Sternburg EL, Gruijs da Silva LA and Dormann D (2022) Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration? Trends Biochem Sci, 47:6–22 Link
Strohm L, Hu Z, Suk Y, Rühmkorf A, Sternburg E, Gattringer V, Riemenschneider H, Berutti R, Graf E, Weishaupt JH, Brill MS, Harbauer AB, Dormann D, Dengjel J, Edbauer D and Behrends C (2022) Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants. Life Sci Alliance, 5:e202101327 Link
Zambusi A*, Novoselc KT*, Hutten S, Kalpazidou S, Koupourtidou C, Schieweck R, Aschenbroich S, Silva L, Yazgili AS, van Bebber F, Schmid B, Möller G, Tritscher C, Stigloher C, Delbridge C, Sirko S, Günes ZI, Liebscher S, Schlegel J, Aliee H, Theis F, Meiners S, Kiebler M, Dormann D* and Ninkovic J* (2022) TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury. Nat Neurosci, 25:1608-1625 (*indicates joint contribution) Link
2021
Baade I*, Hutten S*, Sternburg EL, Pörschke M, Hofweber M, Dormann D# and Kehlenbach RH# (2021) The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors. J Biol Chem, 296:100659 (*indicates joint contribution, #indicates joint correspondence) Link
Dormann D (2021) The chains of stress recovery. Science, 372:1393–1395 Link
Lenard AJ, Hutten S, Zhou Q, Usluer S, Zhang F, Bourgeois BMR, Dormann D and Madl T (2021) Phosphorylation regulates CIRBP arginine methylation, Transportin-1 binding and liquid-liquid phase separation. Front Mol Biosci, 8:1004 Link
Reber S, Jutzi D, Lindsay H, Devoy A, Mechtersheimer J, Levone BR, Domanski M, Bentmann E, Dormann D, Mühlemann O, Barabino SML and Ruepp MD (2021) The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separation. Nucleic Acids Res, 49:7713–7731 Link
Sternburg EL, Gruijs da Silva LA and Dormann D (2021) Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration? Trends Biochem Sci, 47:6–22 Link
2020
Bourgeois B, Hutten S, Gottschalk B, Hofweber M, Richter G, Sternat J, Abou-Ajram C, Göbl C, Leitinger G, Graier WF, Dormann D and Madl T (2020) Nonclassical nuclear localization signals mediate nuclear import of CIRBP. Proc Natl Acad Sci USA, 117:8503–8514 Link
Dormann D (2020) Molecular mechanisms of neurodegeneration. Semin Cell Dev Biol, 99:131–132 Link
Dormann D (2020) FG-nucleoporins caught in the act of liquid–liquid phase separation. J Cell Biol, 219:e20191021 Link
Hutten S and Dormann D (2020) Nucleocytoplasmic transport defects in neurodegeneration - Cause or consequence?Semin Cell Dev Biol, 99:151–162 Link
Hutten S and Dormann D (2020) A quantitative assay to measure stress granule association of proteins and peptidesin semi-permeabilized human cells. Bio-protocol, 10:e3846 Link
Hutten S, Usluer S, Bourgeois B, Simonetti F, Odeh HM, Fare CM, Czuppa M, Hruska-Plochan M, Hofweber M, Polymenidou M, Shorter J, Edbauer D, Madl T and Dormann D (2020) Nuclear import receptors directly bind to arginine-rich dipeptide repeat proteins and suppress their pathological interactions. Cell Rep, 33:108538 Link
2019
Alberti S and Dormann D (2019) Liquid-liquid phase separation in disease. Annu Rev Genet, 53:171–194 Link
Hofweber M and Dormann D (2019) Friend or foe-post-translational modifications as regulators of phase separation and RNP granule dynamics. J Biol Chem, 294:7137–7150 Link
Hutten S and Dormann D (2019) RAN translation down. Nat Neurosci, 22:1379–1380 Link
Ukmar-Godec T, Hutten S, Grieshop MP, Rezaei-Ghaleh N, Cima-Omori MS, Biernat J, Mandelkow E, Söding J, Dormann D and Zweckstetter M (2019) Lysine/RNA-interactions drive and regulate biomolecular condensation. Nat Commun, 10:2909 Link
2018
Ederle H, Funk C, Abou-Ajram C, Hutten S, Funk EBE, Kehlenbach RH, Bailer SM and Dormann D (2018) Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1. Sci Rep, 8:7084 Link
Hock EM, Maniecka Z, Hruska-Plochan M, Reber S, Laferrière F, Sahadevan MK S, Ederle H, Gittings L, Pelkmans L, Dupuis L, Lashley T, Ruepp MD, Dormann D and Polymenidou M (2018) Hypertonic stress causes cytoplasmic translocation of neuronal, but not astrocytic, FUS due to impaired transportin function. Cell Rep, 24:987-1000.e7 Link
Hofweber M, Hutten S, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T and Dormann D (2018) Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation. Cell, 173:706-719.e13 Link
Simandi Z, Pajer K, Karolyi K, Sieler T, Jiang LL, Kolostyak Z, Sari Z, Fekecs Z, Pap A, Patsalos A, Contreras GA, Reho B, Papp Z, Guo X, Horvath A, Kiss G, Keresztessy Z, Vámosi G, Hickman J, Xu H, Dormann D, Hortobagyi T, Antal M, Nógrádi A and Nagy L (2018) Arginine methyltransferase PRMT8 provides cellular stress tolerance in aging motoneurons. J Neurosci, 38:7683–7700 Link
Woodsmith J, Casado-Medrano V, Benlasfer N, Eccles RL, Hutten S, Heine CL, Thormann V, Abou-Ajram C, Rocks O, Dormann D and Stelzl U (2018) Interaction modulation through arrays of clustered methyl-arginine protein modifications. Life Sci Alliance, 1:e201800178 Link
2017
Ederle H and Dormann D (2017) TDP-43 and FUS en route from the nucleus to the cytoplasm. FEBS Lett, 591:1489–1507 Link
Khosravi B, Hartmann H, May S, Möhl C, Ederle H, Michaelsen M, Schludi MH, Dormann D and Edbauer D (2017) Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD. Hum Mol Genet, 26:790–800 Link
Scekic-Zahirovic J, Oussini H El, Mersmann S, Drenner K, Wagner M, Sun Y, Allmeroth K, Dieterlé S, Sinniger J, Dirrig-Grosch S, René F, Dormann D, Haass C, Ludolph AC, Lagier-Tourenne C, Storkebaum E and Dupuis L (2017) Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis. Acta Neuropathol, 133:887–906 Link
2016
Bowden HA and Dormann D (2016) Altered mRNP granule dynamics in FTLD pathogenesis. J Neurochem, 138 Suppl:112–133 Link
Dormann D (2016) FUScinating insights into motor neuron degeneration. EMBO J, 35:1015–1017 Link
Hutten S and Dormann D (2016) hnRNPA2/B1 function in neurodegeneration: it’s a gain, not a loss. Neuron, 92:672–674 Link
Suárez-Calvet M, Neumann M, Arzberger T, Abou-Ajram C, Funk E, Hartmann H, Edbauer D, Kremmer E, Göbl C, Resch M, Bourgeois B, Madl T, Reber S, Jutzi D, Ruepp MD, Mackenzie IRA, Ansorge O, Dormann D and Haass C (2016) Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta Neuropathol, 131:587–604 Link
2015
Jäckel S, Summerer AK, Thömmes CM, Pan X, Voigt A, Schulz JB, Rasse TM, Dormann D, Haass C and Kahle PJ (2015) Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila. Neurobiol Dis, 74:76–88 Link
2013
Bentmann E, Haass C and Dormann D (2013) Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma. FEBS J, 280:4348–4370 Link
Dormann D and Haass C (2013) Fused in sarcoma (FUS): an oncogene goes awry in neurodegeneration. Mol Cell Neurosci, 56:475–486 Link
2012
Dormann D, Madl T, Valori CF, Bentmann E, Tahirovic S, Abou-Ajram C, Kremmer E, Ansorge O, Mackenzie IRA, Neumann M and Haass C (2012) Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J, 31:4258–4275 Link
2011
Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C and Haass C (2011) Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. J Neurosci, 31:1885–1894 Link
Dormann D and Haass C (2011) TDP-43 and FUS: a nuclear affair. Trends Neurosci, 34:339–348 Link
2010
Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IRA, Capell A, Schmid B, Neumann M and Haass C (2010) ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J, 29:2841–2857 Link
2009
Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M and Haass C (2009) Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J Neurochem, 110:1082–1094 Link
2008
Schmid D and Münz C (2008) Localization and MHC class II presentation of antigens targeted for macroautophagy. Methods Mol Biol, 445:213–225 Link
Note: Dormann D = Schmid D before 2007
2007
Lünemann JD, Schmidt J, Schmid D, Barthel K, Wrede A, Dalakas MC and Münz C (2007) Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis. Ann Neurol, 61:476–483 Link
Schmid D and Münz C (2007) Innate and adaptive immunity through autophagy. Immunity, 27:11–21 Link
Schmid D and Münz C (2007) Immune surveillance via self digestion. Autophagy, 3:133–135 Link
Schmid D, Pypaert M and Münz C (2007) Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity, 26:79–92 Link
2006
Schmid D, Dengjel J, Schoor O, Stevanovic S and Münz C (2006) Autophagy in innate and adaptive immunity against intracellular pathogens. J Mol Med (Berl), 84:194–202 Link
2005
Paludan C, Schmid D, Landthaler M, Vockerodt M, Kube D, Tuschl T and Münz C (2005) Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science, 307:593–596 Link
Schmid D and Münz C (2005) Immune surveillance of intracellular pathogens via autophagy. Cell Death Differ, 12 Suppl 2:1519–1527 Link
2004
Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L and Münz C (2004) Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc Natl Acad Sci USA, 101:16606–16611 Link