IPP Research Topics

Ageing & Disease  RNA Biology  DNA Repair & Genome Stability  Epigenetics & Nuclear Dynamics  Bioinformatics & Computational Biology  Gene Regulation & Evolution  Proteostasis & Phase Separation 

Bioinformatics & Computational Biology

Bioinformatics is a powerful tool that allows us to simultaneously analyse large numbers of genes, proteins, or cells. Using computational biology approaches including artificial intelligence, we can decode molecular mechanisms of gene regulation, chromatin organisation, and DNA repair, or screen for mutations in patients on a genome-wide scale. Our scientists use computational biology to identify changes in gene regulation between diseased and normal cells to make predictions about the mechanisms underlying disease.

Key techniques used: Bioinformatics analysis, neural networks, deep learning, mathematical modelling, next-generation sequencing (DNA and RNA-seq), mass spectrometry, high-throughput microscopy, random mutagenesis screening.

Keywords: Artificial intelligence, machine learning, programming, computer vision, modelling.

IPP Groups in Bioinformatics & Computational Biology:

GroupDescriptionInstitute
Julian König

RNA modifications & regulation

IMB 
Katja Luck

Integrative Systems Biology

IMB 
Lukas Stelzl

GENE REGULATION BY LIQUID-LIQUID PHASE SEPARATION

IMB  JGU 
Philipp Wild

Systems Medicine approaches to Age-related Diseases in Humans

UMC 
Sara Vieira-Silva

Human Microbiome Ecology

UMC 
Thomas Hankeln

Globins in the nucleus

JGU