Integrative Systems Biology

Proteins mediate cellular function by interacting with other proteins. The human genome contains tens of thousands of genes, which in turn come in hundreds of thousands of protein-coding variants, some of which can modify protein-protein interactions and result in disease. Furthermore, these interactions vary among different cell types, giving rise to diseases that affect specific tissues.

My research combines computational with experimental methods to predict and characterise the protein-protein interactions and mutations that cause neurodevelopmental disorders (NDDs). I use existing and/or generate new data on protein-protein interactions, their interfaces, brain-related gene expression, and human genetic variants that are associated with NDDs. Employing integrative system-wide protein interaction network analyses, I work to identify molecular mechanisms that underlie brain-specific functions of chromatin remodelling, DNA repair, and transcriptional regulation.

Positions held

Since 2020: Emmy Noether Group Leader, Institute of Molecular Biology (IMB), Mainz

2013 - 2019: Postdoctoral Fellow, Dana-Farber Cancer Institute and Harvard Medical School, USA

2007 - 2008: Research Assistant, EMBL, Heidelberg

Education

2012: PhD in Bioinformatics, University of Strasbourg

2007: Diploma in Bioinformatics, Friedrich Schiller University Jena

2004: Vordiploma in Bioinformatics, Friedrich Schiller University Jena

Funding

I am a fellow of the DFG’s Emmy Noether Program for young investigators, who have granted me €1.6m in funding to support my research ambitions for the coming 6 years. These funds are topped up with IMB core funding.

 

Selected publications by Katja Luck

Luck K*, Kim DK*, Lambourne L*, Spirohn K* … Hill DE#, Vidal M#, Roth FP# and Calderwood MA# (2020) A reference map of the human binary protein interactome. Nature, 580:402–408 (*indicates joint contribution, #indicates joint correspondence) Link

Choi SG*, Olivet J*, Cassonnet P*, Vidalain PO*, Luck K, Lambourne L, Spirohn K, Lemmens I, Santos MD, Demeret C, Jones L, Rangarajan S, Bian W, Coutant EP, Janin YL, Werf SVD, Rivas JDL, Tavernier J, Twizere JC, Hao T, Hill DE, Vidal M#, Calderwood MA# and Jacob Y# (2019) Maximizing binary interactome mapping with a minimal number of assays. Nature Comm  10:3907 Link

Kovacs IA, Luck K, Spirohn K, Wang Y, Pollis C, Schlabach S, Bian W, Kim DK, Kishore N, Hao T, Calderwood MA, Vidal M and Barabási AL (2019) Network-based prediction of protein interactionsNature Comm 10:1240 Link

Vincentelli R*, Luck K*, Poirson J, Polanowska J, Abdat J, Blémont M, Turchetto J, Iv F, Ricquier K, Straub ML, Forster A, Cassonnet P, Borg JP, Jacob Y, Masson M, Nominé Y, Reboul J, Wolff N, Charbonnier S and Travé G (2015) Quantifying domain-ligand affinities and specificities by high-throughput holdup assayNature Methods 12(8):787-93 Link