Human microbiome ecology

Our research focuses on understanding the function of microbial communities, in particular the human gastrointestinal microbiota, in health and disease.

We explore 1) the ecological variation and resilience of the human gut microbiota in health, and 2) the contribution of abnormal microbiota composition (dysbiosis) to pathophysiology, notably in the clinical context of inflammatory, cardiometabolic and neuropsychiatric disorders.

Operating in a quantitative framework, we combine metagenomics, comparative genomics, evolutionary ecology and state-of-the-art computational approaches to understand the role of microbial communities in human health. This includes predicting disease progression and treatment efficacy in order to inform the design of new strategies for personalised medicine.