Publications co-authored by the Flow Cytometry Core Facility


Krause T, Röckendorf N, Meckelein B, Sinnecker H, Schwager C, Möckel S, Jappe U and Frey A (2020) IgE Epitope Profiling for Allergy Diagnosis and Therapy – Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform. Front Immunol, 11:2512 Link

Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D, Remer K, Nurden P, Nurden AT, Dandekar T, Nehez L, Dank M, Braun A, Mezzano D, Abrams SI and Nieswandt B (2020) Platelet glycoprotein VI promotes metastasis through interaction with cancer cell–derived galectin-3. Blood, 135:1146–1160 Link

Redl S*, de Jesus Domingues AM*, Caspani E, Möckel S, Salvenmoser W, Mendez-Lago M and Ketting RF (2020) Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish. Development, doi: 10.1242/dev.193060 (*indicates joint contribution) Link

Sayols S, Klassek J, Werner C, Möckel S, Ritz S, Mendez-Lago M and Soshnikova N (2020) Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors. Development, 147:dev188839 Link


Lucas F, Gil-Pulido J, LaMacchia J, Preffer F, Wallace PK and Lopez P (2019) MiSet RFC Standards: Defining a Universal Minimum Set of Standards Required for Reproducibility and Rigor in Research Flow Cytometry Experiments. Cytom Part A, 97:148–155 Link


Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krüger M, Radyushkin K, Alberi L, Berninger B and Schmidt MHH (2017) Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun, 8:15922 Link

De Azua IR, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D and Lutz B (2017) Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest, 127:4148–4162 Link


Seo EJ, Wiench B, Hamm R, Paulsen M, Zu Y, Fu Y and Efferth T (2015) Cytotoxicity of natural products and derivatives toward MCF-7 cell monolayers and cancer stem-like mammospheres. Phytomedicine, 22:438–443 Link

Zeino M, Paulsen M, Zehl M, Urban E, Kopp B and Efferth T (2015) Identification of new P-glycoprotein inhibitors derived from cardiotonic steroids.Biochem Pharmacol, 93:11–24 Link


Holloschi A, Ritz S, Schäfer I and Kioschis P (2014) Analysis of huntingtin aggregation by fluorescence and FRET microscopy. Pages 217–215 in: Microscopy: Advances in scientific research and education, vol. 1 (ed. Méndez-Vilas A), Formatex, Badajoz  Link


Wiench B, Chen YR, Paulsen M, Hamm R, Schröder S, Yang NS and Efferth T (2013) Integration of different “-omics” technologies identifies inhibition of the IGF1R-Akt-mTOR signaling cascade involved in the cytotoxic effect of shikonin against leukemia cells.Evidence-based Complement Altern Med, 2013:818709 Link


Wiench B, Eichhorn T, Paulsen M and Efferth T (2012) Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells.Evidence-based Complement Altern Med, 2012:726025 Link

Wiench B, Eichhorn T, Korn B, Paulsen M and Efferth T (2012) Utilizing inherent fluorescence of therapeutics to analyze real-time uptake and multi-parametric effector kinetics.Methods, 57:376–382 Link


Paulsen M*, Legewie S*, Eils R, Karaulanov E and Niehrs C (2011) Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci USA, 108:10202–10207 (Editors' Choice in Science 333, 138). (*indicates joint contribution) Link

Publications acknowledging the Flow Cytometry Core Facility


Wong RP, García-Rodríguez N, Zilio N, Hanulová M and Ulrich HD (2020) Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks. Mol Cell, 77:3–16.e4 


Han D*, Schomacher L*, Schüle KM*, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A and Niehrs C (2019) NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. eLife, e49044 (*indicates joint contribution) 


Aasland D, Götzinger L, Hauck L, Berte N, Meyer J, Effenberger M, Schneider S, Reuber EE, Roos WP, Tomicic MT, Kaina B and Christmann M (2019) Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR–CHK1, p21, and NF-κB. Cancer Res, 79:99–113

Gruber L, Abdelfatah S, Fröhlich T, Reiter C, Klein V, Tsogoeva SB and Efferth T (2018) Treatment of multidrug-resistant leukemia cells by novel artemisinin-, egonol-, and thymoquinone-derived hybrid compoundsMolecules, 28: 841

Heidelberger JB, Voigt A, Borisova ME, Petrosino G, Ruf S, Wagner SA and Beli P (2018) Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc functionEMBO Rep, 19: e44754

Mbaveng AT, Manekengb HT, Nguenangb GS, Dzotamb JK, Kuete V and Efferth T (2018) Cytotoxicity of 18 Cameroonian medicinal plants against drug sensitive and multi-factorial drug resistant cancer cellsJ Ethnopharmacology, 222: 21–33

Mbaveng AT, Fotso GW, Ngnintedo D, Kuete V, Ngadjui BT, Keumedjio F, Andrae-Marobela K and Efferth T (2018) Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells. Phytomedicine, 48:112–119

Mbaveng AT, Ndontsac BL, Kuete V, Nguekeuc YMM, Çelikd I, Mbouangouerec R, Tanec P and Efferth T (2018) A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell deathPhytomedicine, 43: 78–85

Nayak T, Trotter J and Sakry D (2018) The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling. Front Cell Neurosci, 12:231

Özenver N, Saeed M, Ömur Demirezer L and Efferth T (2018) Aloe-emodin as drug candidate for cancer therapyOncotarget, 9: 17770–17796

Roovers EF, Kaaij LJT, Redl S, Bronkhorst AW, Wiebrands K, de Jesus Domingues AM, Huang HY, Han CT, Riemer S, Dosch R, Salvenmoser W, Grün D, Butter F, van Oudenaarden A and Ketting RF (2018) Tdrd6a regulates the aggregation of buc into functional subcellular compartments that drive germ cell specificationDev Cell, 46: 285–301.e9

Wanke F, Tang Y, Gronke K, Klebow S, Moos S, Hauptmann J, Shanmugavadivu A, Regen T, Mufazalov IA, Gabriel LA, Reißig S, Diefenbach A, Kurschus FC and Waisman A (2018) Expression of IL-17F is associated with non-pathogenic Th17 cellsJ Mol Med, 96: 819–829

Zimmermann T, Maroso M, Beer A, Baddenhausen S, Ludewig S, Fan W, Vennin C, Loch S, Berninger B, Hofmann C, Korte M, Soltesz I, Lutz B and Leschik J (2018) Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus.Cereb cortex, 28:4454–4471


Van Acker A, Gronke K, Biswas A, Martens L, Saeys Y, Filtjens J, Taveirne S, Van Ammel E, Kerre T, Matthys P, Taghon T, Vandekerckhove B, Plum J, Dunay IR, Diefenbach A and Leclercq G (2017) A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 propertiesCell Rep, 19: 1431–1443

Dzama MM, Nigmatullina L, Sayols S, Kreim N and Soshnikova N (2017) Distinct populations of embryonic epithelial progenitors generate Lgr5+ intestinal stem cellsDev Biol, 432: 258–264

Kazakevych J, Sayols S, Messner B, Krienke C and Soshnikova N (2017) Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cellsNucleic Acids Res, 45: 5770–5784

Kuete V, Mbaveng AT, Sandjo LP, Zeino M and Efferth T (2017) Cytotoxicity and mode of action of a naturally occurring naphthoquinone, 2-Acetyl-7-methoxynaphtho[2,3-B]furan-4,9-quinone towards multi-factorial drug-resistant cancer cellsPhytomedicine, 33: 62–68

Nigmatullina L, Norkin M, Dzama MM, Messner B, Sayols S and Soshnikova N (2017)  Id2 controls specification of Lgr5(+) intestinal stem cell progenitors during gut developmentEMBO J, 36: 869–885


Kaymak A and Richly H (2016) Zrf1 controls mesoderm lineage genes and cardiomyocyte differentiationCell Cycle, 15: 3306–3317

Pataskar A, Jung J, Smialowski P, Noack F, Calegari F, Straub T and Tiwari VK (2016) NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal programEMBO J, 35: 24-45


Kirmes I, Szczurek A, Prakash K, Charapitsa I, Heiser C, Musheev M, Schock F, Fornalczyk K, Ma D, Birk U, Cremer C and Reid G (2015) A transient ischemic environment induces reversible compaction of chromatinGenome Biology, 16: 246

Krieg B, Hirsch M, Scholz E, Nuhn L, Tabujew I, Bauer H, Decker S, Khobta A, Schmidt M, Tremel W, Zentel R, Peneva K, Koynov K, Mason AJ and Helm M (2015) New techniques to assess in vitro release of siRNA from nanoscale polyplexesPharm Res, 32: 1957-74

Sahu SK, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M and Tiwari V (2015) JNK-dependent gene regulatory circuitry governs mesenchymal fateEMBO J, 34: 2162-2181

Sakry D, Yigit H, Dimou L and Trotter J (2015) Oligodendrocyte precursor cells synthesize neuromodulatory factorsPLoS One, 10: e0127222

Stangenberg R, Wu Y, Hedrich J, Kurzbach D, Wehner D, Weidinger G, Kuan SL, Jansen MI, Jelezko F, Luh-mann HJ, Hinderberger D, Weil T and Müllen K (2015) A polyphylene dendrimer drug transporter with precisely positioned amphiphilic surface patchesAdv Healthc Mater, 4: 377-84

Wu CF and Efferth T (2015) Miltirone induces G2/M cell cycle arrest and apoptosis in CCRF-CEM acute lymphoblastic leukemia cellsJ Nat Prod, 78: 1339-1347

Zeino M, Brenk R, Gruber L, Zehl M, Urban E, Kopp B and Efferth T (2015) Cytotoxicity of cardiotonic steroids in sensitive and multi-drug resistant leukemia cells and the link with Na+/K+-ATPaseJ Steroid Biochem, 150: 97-111


Hamm R, Zeino M, Frewert S and Efferth T (2014) Up-regulation of cholesterol associated genes as novel resistance mechanism in glioblastoma cells in response to archazolid BToxicol Appl Pharmacol, 281: 78-86

Hamm R, Chen YR, Seo EJ, Zeino M, Wu CF, Müller R, Yang NS and Efferth T (2014) Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cellsBiochemical Pharmacol, 91: 18-30