Coagulation signaling in innate immunity


  • Since 2014: Scientific Director CTH Mainz
  • Since 2013: Alexander von Humboldt Professor, CTH Mainz
  • Since 2007: Margaret Thatcher Professor of Biological Chemistry, Thrombosis Research Institute, London, U.K. (external affiliation)
  • Since 2005: Professor of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA
  • 1992-2005: Assistant to Associate Professor, The Scripps Research Institute
  • 1990-1992: Senior Research Associate, The Scripps Research Institute
  • 1988-1990: DFG Exchange Visitor, Department of Immunology, Scripps Clinic
  • 1987-1988: Research Associate, Max-Planck Society


  • 1987: Dr. med. (summa cum laude) Justus-Liebig University, Giessen; Advisor: Prof. Müller-Berghaus, Max-Planck Society
  • 1984-1986: Doctoral Fellowship, Max-Planck Society
  • 1977-1984: Medicine, Justus-Liebig University, Giessen

Most relevant publications by Wolfram Ruf

Ahamed J, Versteeg HH, Kerver M, Chen VM, Mueller BM, Hogg PJ and Ruf W (2006). Disulfide isomerization switches tissue factor from coagulation to cell signaling. Proc Natl Acad Sci USA, 103, 13932-13937

Versteeg HH, Schaffner F, Kerver M, Petersen HH, Ahamed J., Felding-Habermann B, Takada Y, Mueller B and Ruf W (2008). Inhibition of tissue factor signaling suppresses tumor growth.  Blood, 111, 190-199

Badeanlou L, Furlan-Freguia C, Yang G, Ruf W and Samad F (2011). Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation. Nat Med, 17, 1490-1497

Furlan-Freguia C, Marchese P, Gruber A, Ruggeri ZM and Ruf W (2011). P2X7 signaling triggers tissue factor-dependent thrombosis in mice.  J Clin Invest, 121, 2932-2944

Disse J, Petersen HH, Larsen KS, Persson E, Esmon N, Esmon CT, Teyton L, Petersen LC and Ruf W (2011). The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem, 286, 5756-5767

Reinhardt C, Bergentall M, Greiner TU, Schaffner F, Ostergren-Lunden G, Petersen LC, Ruf W and Backhed F (2012). Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling. Nature, 483, 627-631

Schaffner F, Yokota N, Carneiro-Lobo T, Kitano M, Schaffer M, Anderson GM, Mueller BM, Esmon CT and Ruf W (2013). Endothelial protein C receptor function in murine and human breast cancer development. PloS One,  8, e61071

Rothmeier AS, Marchese P, Petrich BG, Furlan-Freguia C, Ginsberg MH, Ruggeri ZM and Ruf W (2015). Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. J Clin Invest, 125, 1471-1484

Liang HP, Kerschen EJ, Hernandez I, Basu S, Zogg M, Botros F, Jia S, Hessner MJ, Griffin JH, Ruf W  and Weiler H (2015). EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood, 125, 2845-2854

Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W and Lapidot T (2015). PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat Med, 21, 1307-1317

Research website