The role of DNA damage in the pathogenesis of nitrate tolerance

Andreas Daiber

Positions held

  • Since 2008: Professor (W2) in Molecular Cardiology, University Medical Center Mainz
  • Since 2006: Head of Molecular Cardiology, University Medical Center Mainz
  • 2000-2006: Postdoc, University of Konstanz and Exp. Cardiology, University Hospital Hamburg-Eppendorf and University Medical Center Mainz


  • 2000: PhD in Biological Chemistry, University of Konstanz
  • 1997: Diploma in Chemistry, Biological Chemistry, University of Konstanz

Most relevant publications by Andreas Daiber

Daiber A, Frein D, Namgaladze D and Ullrich V (2002). Oxidation and nitrosation in the nitrogen monoxide / superoxide system. J Biol Chem, 277, 11882-11888

Sydow K*, Daiber A* (equal contribution), Oelze M, Chen Z, August M, Wendt M, Ullrich V, Mulsch A, Schulz E, Keaney Jr JF, Stamler JS and Munzel T (2004). Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance. J Clin Invest, 113, 482-489

Wenzel P, Oelze M, Coldewey M, Hortmann M, Seeling A, Hink U, Mollnau H, Warnholtz A, Stalleicken D, Weiner H, Lehmann J, Li H, Förstermann U, Münzel T and Daiber A (2007). Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates. Arterioscler Thromb Vasc Biol, 27, 1729-1735

Schuhmacher S, Wenzel P, Schulz E, Oelze M, Mang C, Kamuf J, Gori T, Jansen T, Knorr M, Karbach S, Hortmann M, Mäthner F, Bhatnagar A, Förstermann U, Li H, Münzel T and Daiber A (2010). Pentaerithrityl tetranitrate improves angiotensin II induced vascular dysfunction via induction of heme oxygenase-1. Hypertension, 55, 897-904

Schuhmacher S, Oelze M, Bollmann F, Kleinert H, Otto C, Heeren T, Steven S, Hausding M, Knorr M, Pautz A, Reifenberg K, Schulz E, Gori T, Wenzel P, Münzel T and Daiber A (2011). Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy. Diabetes, 60, 2608–2616

Research website