Development and regulation of IL-17 producing cells during inflammation

Ari Waisman

Position

  • Since 2011: W3 Univ. Prof. and Director, Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz
  • 2010-2011: Acting Director, Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz
  • 2005-2010: W2 Univ. Prof. in the I. Medical Department, University Medical Center of the Johannes Gutenberg-University, Mainz
  • 2001-2005: Independent Group Leader, Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, Cologne, Germany
  • 2000-2001: Research Associate, Department of Immunology, Institute for Genetics, University of Cologne, Cologne, Germany
  • 1996-2000: Post-Doctoral fellow, Department of Immunology, Institute for Genetics, University of Cologne, (K. Rajewsky), Cologne, Germany
  • 1994-1996: Post-Doctoral fellow, Department of Immunology, The Weizmann Institute of Science, (L. Steinman), Rehovot, Israel

Education

  • 1986-1990: Ph.D. with E. Mozes, Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel
  • 1986-1988: M.Sc. with Y. Aloni and O. Laub, Department of Genetics, The Weizmann Institute of Science, Rehovot, Israel
  • 1983-1986: B.Sc. Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel

Recent publications by Ari Waisman

Wanke F, Tang Y, Gronke K, Klebow S, Moos S, Hauptmann J, Shanmugavadivu A, Regen T, Mufazalov IA, Gabriel LA, Reißig S, Diefenbach A, Kurschus FC, Waisman A (2018). Expression of IL-17F is associated with non-pathogenic Th17 cells. J Mol Med (Berl), doi: 10.1007/s00109-018-1662-5. [Epub ahead of print]

Wunderlich CM, Ackermann PJ, Ostermann AL, Adams-Quack P, Vogt MC, Tran ML, Nikolajev A, Waisman A, Garbers C, Theurich S, Mauer J, Hövelmeyer N, Wunderlich FT (2018). Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nat Commun, 9(1):1646

Tusi BK, Wolock SL, Weinreb C, Hwang Y, Hidalgo D, Zilionis R, Waisman A, Huh JR, Klein AM, Socolovsky M (2018). Population snapshots predict early haematopoietic and erythroid hierarchies. Nature, 555(7694):54-60

Mufazalov IA, Kuschmann J, Andruszewski D, Masri J, Gabriel LA, Adams P, Reissig S, Hövelmeyer N, Waisman A (2017). Balanced Bcl-3 expression in murine CD4+ T cells is required for generation of encephalitogenic Th17 cells. Eur J Immunol, 47, 1335-1341

Kitic M, Karram K, Israel N, Yogev N, Lacher SM, Tang Y, Yigit H, Bauer J, Wanke F, Knezovic A, Trotter J, Kurschus FC, Waisman A (2017). NG2 plays a role in neuroinflammation but is not expressed by immune cells. Acta Neuropathol. 134, 325-327

Lacher SM, Bruttger J, Kalt B, Berthelet J, Rajalingam K, Wörtge S, Waisman A (2017). HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival. Cell Death Dis, 8, e2824

Mufazalov IA, Schelmbauer C, Regen T, Kuschmann J, Wanke F, Gabriel LA, Hauptmann J, Müller W, Pinteaux E, Kurschus FC, Waisman A (2017). IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells. EMBO J, 36, 102-115.

Research website