Development and regulation of IL-17 producing cells during inflammation

Position

  • Since 2011: W3 Univ. Prof. and Director, Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz
  • 2010-2011: Acting Director, Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz
  • 2005-2010: W2 Univ. Prof. in the I. Medical Department, University Medical Center of the Johannes Gutenberg-University, Mainz
  • 2001-2005: Independent Group Leader, Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, Cologne, Germany
  • 2000-2001: Research Associate, Department of Immunology, Institute for Genetics, University of Cologne, Cologne, Germany
  • 1996-2000: Post-Doctoral fellow, Department of Immunology, Institute for Genetics, University of Cologne, (K. Rajewsky), Cologne, Germany
  • 1994-1996: Post-Doctoral fellow, Department of Immunology, The Weizmann Institute of Science, (L. Steinman), Rehovot, Israel

Education

  • 1986-1990: Ph.D. with E. Mozes, Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel
  • 1986-1988: M.Sc. with Y. Aloni and O. Laub, Department of Genetics, The Weizmann Institute of Science, Rehovot, Israel
  • 1983-1986: B.Sc. Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel

Recent publications by Ari Waisman

  1. Waisman A, Ebering A. (2019). Unraveling the T-B tangle in anti-CD20 multiple sclerosis therapy. Proc Natl Acad Sci U S A, pii: 201919044

  2. Kitic M, See P, Bruttger J, Ginhoux F, Waisman A. (2019). Novel Microglia Depletion Systems: A Genetic Approach Utilizing Conditional Diphtheria Toxin Receptor Expression and a Pharmacological Model Based on the Blocking of Macrophage Colony-Stimulating Factor 1 Receptor. Methods Mol Biol, 2034:217-230

Wanke F, Tang Y, Gronke K, Klebow S, Moos S, Hauptmann J, Shanmugavadivu A, Regen T, Mufazalov IA, Gabriel LA, Reißig S, Diefenbach A, Kurschus FC, Waisman A (2018). Expression of IL-17F is associated with non-pathogenic Th17 cells. J Mol Med (Berl), doi: 10.1007/s00109-018-1662-5. [Epub ahead of print]

Wunderlich CM, Ackermann PJ, Ostermann AL, Adams-Quack P, Vogt MC, Tran ML, Nikolajev A, Waisman A, Garbers C, Theurich S, Mauer J, Hövelmeyer N, Wunderlich FT (2018). Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nat Commun, 9(1):1646

Tusi BK, Wolock SL, Weinreb C, Hwang Y, Hidalgo D, Zilionis R, Waisman A, Huh JR, Klein AM, Socolovsky M (2018). Population snapshots predict early haematopoietic and erythroid hierarchies. Nature, 555(7694):54-60

Turnescu T, Arter J, Reiprich S, Tamm ER, Waisman A, Wegner M (2017). Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes. Glia, 66(2):279-294

Mufazalov IA, Kuschmann J, Andruszewski D, Masri J, Gabriel LA, Adams P, Reissig S, Hövelmeyer N, Waisman A (2017). Balanced Bcl-3 expression in murine CD4+ T cells is required for generation of encephalitogenic Th17 cells. Eur J Immunol, 47, 1335-1341

Kitic M, Karram K, Israel N, Yogev N, Lacher SM, Tang Y, Yigit H, Bauer J, Wanke F, Knezovic A, Trotter J, Kurschus FC, Waisman A (2017). NG2 plays a role in neuroinflammation but is not expressed by immune cells. Acta Neuropathol. 134, 325-327

Lacher SM, Bruttger J, Kalt B, Berthelet J, Rajalingam K, Wörtge S, Waisman A (2017). HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival. Cell Death Dis, 8, e2824

Mufazalov IA, Schelmbauer C, Regen T, Kuschmann J, Wanke F, Gabriel LA, Hauptmann J, Müller W, Pinteaux E, Kurschus FC, Waisman A (2017). IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells. EMBO J, 36, 102-115.

Research website