Biology of Non-coding RNA

René Ketting

Positions held

  • Since 2015: Executive Director, IMB, Mainz
  • Since 2012: Scientific Director, Institute of Molecular Biology (IMB), Mainz;
    Professor, Faculty of Biology, University of Mainz
  • Since 2010: Professor of Epigenetics in Development, University of Utrecht
  • 2005-2012: Group Leader, Hubrecht Institute, Utrecht
  • 2000-2004: Postdoctoral Researcher, Hubrecht Laboratory, Utrecht
  • 2000: Postdoctoral Researcher, Cold Spring Harbor Laboratories


  • 2000: PhD in Molecular Biology, Netherlands Cancer Institute, Amsterdam
  • 1994: Masters in Chemistry, University of Leiden

Most relevant publications by René Ketting

Kaaij LJ, Mokry M, Zhou M, Musheev M, Geeven G, Melquiond AS, de Jesus Domingues AM, de Laat W, Niehrs C, Smith AD, Ketting RF (2016). Enhancers reside in a unique epigenetic environment during early zebrafish development. Genome Biology, 17(1):146

de Albuquerque BF, Placentino M and Ketting RF (2015). Maternal piRNAs are essential for germline development following de novo establishment of endo-siRNAs in Caenorhabditis elegans. Dev Cell, 34, 448-456

Roovers EF, Rosenkranz D, Mahdipour M, Han CT, He N, Chuva de Sousa Lopes SM, van de Westerlaken LAJ, Zischler H, Butter F, Roelen BAJ and Ketting RF (2015). Piwi proteins and piRNAs in mammalian oocytes and early embryos. Cell Rep, 10, 2069-2082

de Albuquerque BFM, Luteijn MJ, Cordeiro Rodrigues RJ, van Bergeijk P, Waaijers S, Kaaij LJT, Klein H, Boxem M and Ketting RF (2014). PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans. Genes Dev, 28, 683-688

van Wolfswinkel JC, Claycomb JM, Batista PJ, Mello CC, Berezikov E and Ketting RF (2009). CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. Cell, 139, 135-148

Houwing S, Kamminga LM, Berezikov E, Cronembold D, Girard A, van den Elst H, Filippov DV, Blaser H, Raz E, Moens CB, Plasterk RH, Hannon GJ, Draper BW and Ketting RF (2007). A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in zebrafish. Cell, 129, 69-82

  Research website