Synthetic biophysics of protein disorder

Edward Lemke

Positions held

  • Since 2018: Adjunct Director, Institute of Molecular Biology (IMB) & Professor of Synthetic Biophysics, Johannes Gutenberg University, (JGU), Mainz
  • Since 2009: Group Leader, EMBL, Heidelberg, Germany
  • 2005-2008:  Research Associate (Postdoc), The Scripps Research Institute, La Jolla, CA

Education

  • 2005: PhD MPI for Biophysical Chemistry and University of Göttingen, Germany
  • 2001: Diploma in Chemistry, Technical University of Berlin, Germany
  • 2001: Master of Science, University of Oklahoma, USA

Recent publications by Edward Lemke

Tan PS, Aramburu IV, Mercadante D, Tyagi S, Chowdhury A, Spitz D, Shammas SL, Gräter F, Lemke EA (2018). Two Differential Binding Mechanisms of FG-Nucleoporins and Nuclear Transport Receptors. Cell Rep. Mar 27;22(13):3660-3671. doi: 10.1016/j.celrep.2018.03.022

Fuertes G, Banterle N, Ruff KM, Chowdhury A, Mercadante D, Koehler C, Kachala M, Estrada Girona G, Milles S, Mishra A, Onck PR, Gräter F, Esteban-Martín S, Pappu R V, Svergun DI and Lemke EA (2017).  Decoupling of Size and Shape Fluctuations in Heteropolymeric Sequences Reconciles Discrepancies in SAXS vs. FRET Measurements. Proc Natl Acad Sci USA, 114: E6342–E6351

Nikić I, Estrada Girona G, Kang JH, Paci G, Mikhaleva S, Koehler C, Shymanska N V., Ventura Santos C, Spitz D and Lemke EA (2016).  Debugging Eukaryotic Genetic Code Expansion for Site-Specific Click-PAINT Super-Resolution Microscopy. Angew Chemie Int Ed, 55: 16172–16176

Koehler C, Sauter PF, Wawryszyn M, Girona GE, Gupta K, Landry JJM, Fritz MH-Y, Radic K, Hoffmann J-E, Chen ZA, Zou J, Tan PS, Galik B, Junttila S, Stolt-Bergner P, Pruneri G, Gyenesei A, Schultz C, Biskup MB, Besir H, Benes V, Rappsilber J, Jechlinger M, Korbel JO, Berger I, Braese S and Lemke EA (2016).  Genetic Code Expansion for Multiprotein Complex Engineering. Nat Methods, 13: 997–1000

Milles S, Mercadante D, Aramburu IV, Jensen MR, Banterle N, Koehler C, Tyagi S, Clarke J, Shammas SL, Blackledge M, Gräter F and Lemke EA (2015). Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors. Cell, 163: 734–745.

IMB research website
Lemke lab website
EMBL website