Primary cilia and miRNA


  • Since 2015: Junior Professor, Institute of Molecular Physiology, Johannes Gutenberg University, Mainz
  • 2012-2014: Research Fellow, National Eye Institute, National Institute of Health
  • 2008-2011: Postdoctoral Fellow, National Institute of Deafness and Communication Disorders, National Institute of Health


  • 2003-2008: University College London, UK, PhD - Mutational and Functional Analyses of Bardet-Biedl syndrome
  • 2003: University of Bath, UK, Master of Biochemistry (MBiochem) (II-I)

Most relevant publications by Helen May-Simera

May-Simera HL et al (2016). Loss of Macf1 abolishes ciliogenesis and disrupts apicobasal polarity establishment in the retina. Cell Rep, 17, 1399-1413

May-Simera H (2016). Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea. J Vis Exp, 108, doi: 10.3791/53559

Rachel R, Yamomoto E, Dewanjee M, May-Simera H, Sergeev Y, Hackett A, Pohida K, Munasinghe, J, Gotoh, N, Wickstead, B, Fariss, R, Dong L, Li T and Swaroop A (2015). CEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathies. Hum Mol Genet, 24, 3775-3791

May-Simera HL et al (2014). Ciliary proteins Bbs8 and Ift20 regulate planar cell polarity in the cochlea. Development,  142, 555-566

Ezan J, Lasvaux L, Gezer A, Novakovic A, May-Simera H, Belotti E, Lhoumeau AC, Beer-Hammer S, Borg JP, Le Bivic A, Nürnberg B, Sans N and Montcouquiol M (2013). Primary cilium migration depends on G-protein signaling control of  subapical cytoskeleton. Nat Cell Bio, 15, 1107-1115

Rachel RA and May-Simera HL et al (2012). Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis. J Clin Invest, 12, 1233-1245

May-Simera H and Kelley MW (2012). Examining planar cell polarity in the mammalian cochlea. Methods Mol Biol, 839, 157-171

May-Simera HL et al (2010). Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish. Dev Biol, 345, 215-225

May-Simera HL et al (2009). Patterns of expression of Bardet-Biedl syndrome proteins in the mammalian cochlea suggest noncentrosomal functions. J Comp Neurol, 514, 174-188

Ross AJ and May-Simera H et al (2005). Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet, 37, 1135-1140


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