Lineage reprogramming glia into neurons

Positions held

  • Since 2012: Professor, University Medical Center of the Johannes Gutenberg University Mainz
  • 2011-2012: Senior Lecturer in Physiology, Department of Physiological Genomics, Ludwig-Maximilians University Munich
  • 2005: Lecturer in Physiology, Department of Physiological Genomics, Ludwig-Maximilians University Munich
  • 2003-2005: Senior Research Associate at the Institute of Stem Cell Research, Helmholtz Zentrum Munich
  • 2000-2003: Group leader at the Department of Neuroimmunology, Max Planck Institute of Neurobiology


  • 2011: Habilitation and venia legendi, Faculty of Medicine (Physiology), Ludwig-Maximilians University Munich
  • 1993-1996: PhD with Dr. H. Thoenen, Max-Planck Institute of Psychiatry (now Neurobiology), Martinsried/Munich
  • 1992: Diploma in Biology, Ludwig-Maximilians University Munich

Most relevant publications by Benedikt Berninger

Gascón S, Mureno E, Masserdotti G, Ortega F, Russo GL, Petrik D, Deshpande A, Heinrich C, Karow M, Roberston SP, Schroeder T, Beckers J, Irmler M, Berndt C, Friedmann Angeli JP, Conrad M, Berninger B and Götz M (2016). Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming. Cell Stem Cell, 18, 396-409

Bergami M, Masserdotti G, Temprana SG, Motori E, Eriksson T, Göbel J, Yang SM, Conzelmann K-K, Schinder AF, Götz M and Berninger B (2015). A critical period of experience dependent remodelling of adult-born neuron connectivity. Neuron, 85, 710-717

Heinrich C, Spagnoli FM and Berninger B (2015). In vivo reprogramming for tissue repair. Nat Cell Biol, 17, 204-211

Heinrich C, Bergami M, Gascón S, Lepier A, Viganò F, Dimou L, Sutor B, Berninger B* and  Götz M* (2014). Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex. Stem Cell Reports, 3, 1000-1014 * Co-senior authors

Ortega F, Gascón S, Masserdotti G, Deshpande A, Simon S, Fischer J, Dimou L, Lie DC, Schroeder T and Berninger B (2013). Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signaling. Nat Cell Biol, 15, 602-613

Deshpande A, Bergami M, Ghanem A, Conzelmann K-K, Lepier A, Götz M and Berninger B (2013). Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb. Proceedings of the National Academy of Sciences USA, 110, E1152-1161

Karow M, Sánchez R, Schichor C, Masserdotti G, Ortega F, Heinrich C, Gascón S, Khan MA, Lie DC, Dellavalle A, Cossu G, Goldbrunner R, Götz M* and Berninger B* (2012). Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells. Cell Stem Cell, 11, 471-476. * Co-senior authors.

Ortega F, Costa MR, Simon-Ebert T, Schroeder T, Götz M and Berninger B (2011). Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single cell level. Nature Protocols, 6, 1847-1859

Costa MR, Ortega F, Brill MS, Beckervordersandforth R, Petrone C, Schroeder T, Götz M and Berninger B (2011). Continuous live imaging of adult neural stem cell division and lineage progression. Development, 138, 1057-1068

Heinrich C, Blum R, Gascón S, Masserdotti G, Tripathi P, Sánchez R, Tiedt S, Schroeder T, Götz M* and Berninger B* (2010). Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biology, 8, e1000373


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