Maintenance of genome stability

Positions held

  • Since 2018: Executive Director, IMB, Mainz
  • Since 2013: Scientific Director, Institute of Molecular Biology (IMB), Mainz; Professor, Faculty of Biology, University of Mainz
  • 2004-2012: Group Leader, Cancer Research UK London Research Institute, Clare Hall Laboratories
  • 2000-2004: Group Leader, Max Planck Institute for Terrestrial Microbiology, Marburg
  • 1998-2000: Postdoc, Max Planck Institute for Biochemistry, Martinsried
  • 1997-1998: Postdoc, University of Heidelberg


  • 2004: Habilitation, Faculty of Biology (Genetics), Philipps University Marburg
  • 1996: PhD in Chemistry, University of California, Berkeley
  • 1992: Diploma in Biology, Georg-August-University Göttingen

Recent publications by Helle Ulrich

Wong RP, García-Rodríguez N, Zilio N, Hanulová M and Ulrich HD (2020). Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks. Mol Cell, 77:3–16.e4

Lockhart A, Pires VB, Bento F, Kellner V, Luke-Glaser S, Yakoub G, Ulrich HD and Luke B (2019). RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids. Cell Rep, 29:2890–2900.e5 Link

Renz C, Tröster V, Albert TK, Santt O, Jacobs SC, Khmelinskii A and Ulrich HD (2019). The ubiquitin-conjugating enzyme Ubc13-Mms2 cooperates with a family of FYVE-type-RING ubiquitin protein ligases in K63-polyubiquitylation at internal membranes. bioRxiv, doi: 10.1101/575241 Link

Sriramachandran AM, Meyer-Teschendorf K, Pabst S, Ulrich HD, Gehring NH, Hofmann K, Praefcke GJK and Dohmen RJ (2019). Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain. Nat Commun, 10:3678

García-Rodríguez N, Wong RP and Ulrich HD (2018). The helicase Pif1 functions in the template switching pathway of DNA damage bypass. Nucleic Acids Res, 46: 8347–8356

García-Rodríguez N, Morawska M, Wong, RP, Daigaku Y and Ulrich HD (2018). Spatial separation between replisome- and template-induced replication stress signaling. EMBO J, 37(9), pii: e98369

Hung SH, Wong RP, Ulrich HD, Kao CF (2017). Monoubiquitylation of histone H2B contributes to the bypass of DNA damage during and after DNA replication. Proc Natl Acad Sci USA, 114, E2205-E2214

Zilio N, Eifler-Olivi K, Ulrich HD (2017). Functions of SUMO in the Maintenance of Genome Stability. Adv Exp Med Biol, 963, 51-87

García-Rodríguez N, Wong RP and Ulrich HD (2016). Functions of ubiquitin and SUMO in DNA replication and replication stress. Front Genet, 7, 8

Kanu N, Zhang T, Burrell RA, Chakraborty A, Cronshaw J, DaCosta C, Grönroos E, Pemberton HN, Anderton E, Gonzalez L, Sabbioneda S, Ulrich HD and Behrens A (2016). RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene, 35, 4009-4019

Research website