Human microbiome ecology
The Vieira-Silva Lab explores the ecology of host-associated microbial communities, with a focus on the human gastrointestinal tract. Our research focuses on understanding…
Ubiquitin, SUMO & the maintenance of genome stability
Our lab studies the regulatory mechanisms that contribute to ensuring the complete and accurate duplication of a cell’s genetic information in…
Genetic diseases of the central nervous system
In our genetics clinic, we see a large variety of patients with rare diseases, with a focus on neurodevelopmental and neurodegenerative disorders.…
Chromosome fragility & 3D chromosome organisation
Our lab focuses on understanding how cells maintain the stability of their genome in the context of 3D genome organisation. We are interested in…
Lipid homeostasis in ageing and longevity
Ageing is characterised by the gradual decline of tissue function. This decline also increases susceptibility to multiple diseases, including cardiovascular…
Regulation of heterochromatin in response to genotoxic stress
The epigenetic memory of a cell is shaped by pathways that establish, erase and maintain chromatin marks. Lysine 9 methylation on…
Synthetic biophysics of protein disorder
We focus on studying intrinsically disordered proteins (IDPs), which constitute up to 50% of the eukaryotic proteome. Paradoxically, they are most famous…
Proteome organisation & dynamics
The functional state of a cell is ultimately defined by the state of its proteome, i.e. abundance, localisation, turnover and mobility of all proteins and their…
Biology of gene dosage alterations
Research in our laboratory focuses on elucidating the fundamental mechanisms and physiological relevance of gene copy number for regulating cellular function in…