Maternal mRNA regulation Gene expression ultimately depends on translation. Although mRNAs serve as templates for protein production, mRNA and protein levels often correlate poorly. Translational…
Proteome organisation & dynamics
The functional state of a cell is ultimately defined by the state of its proteome, i.e. abundance, localisation, turnover and mobility of all proteins and their…
Synthetic biophysics of protein disorder
We focus on studying intrinsically disordered proteins (IDPs), which constitute up to 50% of the eukaryotic proteome. Paradoxically, they are most famous…
Regulation of heterochromatin in response to genotoxic stress
The epigenetic memory of a cell is shaped by pathways that establish, erase and maintain chromatin marks. Lysine 9 methylation on…
Lipid homeostasis in ageing and longevity
Ageing is characterised by the gradual decline of tissue function. This decline also increases susceptibility to multiple diseases, including cardiovascular…
Chromosome fragility & 3D chromosome organisation
Our lab focuses on understanding how cells maintain the stability of their genome in the context of 3D genome organisation. We are interested in…
Genetic diseases of the central nervous system
In our genetics clinic, we see a large variety of patients with rare diseases, with a focus on neurodevelopmental and neurodegenerative disorders.…
Ubiquitin, SUMO & the maintenance of genome stability
Our lab studies the regulatory mechanisms that contribute to ensuring the complete and accurate duplication of a cell’s genetic information in…