Regulation of heterochromatin in response to genotoxic stress
The epigenetic memory of a cell is shaped by pathways that establish, erase and maintain chromatin marks. Lysine 9 methylation on…
Lipid homeostasis in ageing and longevity
Ageing is characterised by the gradual decline of tissue function. This decline also increases susceptibility to multiple diseases, including cardiovascular…
Chromosome fragility & 3D chromosome organisation
Our lab focuses on understanding how cells maintain the stability of their genome in the context of 3D genome organisation. We are interested in…
Genetic diseases of the central nervous system
In our genetics clinic, we see a large variety of patients with rare diseases, with a focus on neurodevelopmental and neurodegenerative disorders.…
Ubiquitin, SUMO & the maintenance of genome stability
Our lab studies the regulatory mechanisms that contribute to ensuring the complete and accurate duplication of a cell’s genetic information in…
Transgenerational consequences of DNA damage
One of the most fascinating facts of biology is that one organism can develop two fundamentally distinct cellular programmes: the somatic programme,…
Protein disorder in transcription
Transcription is a fundamental process important for all living things. It needs to be precisely executed for cells to function properly during normal growth and in…
Neurocognitive mechanisms of mental resilience
Within our research area “Healthy ageing, neurodegeneration and neuropsychiatry”, led by Kristina Endres, Katharina Geschke/Isabel Heinrich and…
Integrative systems biology
Overview Genes do not function in isolation. Instead, their products, often proteins, engage in a multitude of physical and functional interactions with other molecules in…
Molecular mechanisms of RNA-binding protein dysfunction in neurodegenerative diseases
Our research focuses on the molecular mechanisms of neurodegenerative diseases, most notably FTD (frontotemporal…