Publications co-authored by the Flow Cytometry Core Facility


Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krüger M, Radyushkin K, Alberi L, Berninger B and Schmidt MHH. (2017). Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun, 8: 15922. Link

De Azua IR, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D and Lutz B. (2017). Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest, 127: 4148–4162. Link


Seo EJ, Wiench B, Hamm R, Paulsen M, Zu Y, Fu Y and Efferth T. (2015). Cytotoxicity of natural products and derivatives toward MCF-7 cell monolayers and cancer stem-like mammospheres. Phytomedicine, 22: 438–443. Link

Zeino M, Paulsen M, Zehl M, Urban E, Kopp B and Efferth T. (2015). Identification of P-glycoprotein inhibitors derived from cardiotonic steroids. Biochemical Pharmacology, 93: 11–24. Link


Holloschi A, Ritz S, Schäfer I and Kioschis P. (2014). Analysis of huntingtin aggregation by fluorescence and FRET microscopy. pages 217–225, In: Microscopy: Advances in scientific research and education. Vol. 1. Méndez-Vilas A (ed). Formatex, Badajoz. 


Wiench B, Chen YR, Paulsen M, Hamm R, Schröder S, Yang NS and Efferth T. (2013). Integration of different "-omics" technologies identifies inhibition of the IGF1R-Akt-mTOR signaling cascade involved in the cytotoxic effect of shikonin against leukemia cells. Evid Based Complement Alternat Med, 2013: 818709. Link


Wiench B, Eichhorn T, Paulsen M and Efferth T. (2012). Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells. Evid Based Complement Alternat Med, 2012: 726025. Link

Wiench B, Eichhorn T, Korn B, Paulsen M and Efferth T. (2012). Utilizing inherent fluorescence of thera-peutics to analyse real-time uptake and multi-parametric effector kinetics. Methods, 57: 376–382. Link


Paulsen M*, Legewie S*, Eils R, Karaulanov E and Niehrs C. (2011). Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci USA, 108: 10202–10207.(Editors' Choice in Science 333, 138). (*indicates joint contribution) Link

Publications acknowledging the Flow Cytometry Core Facility


Gruber L, Abdelfatah S, Fröhlich T, Reiter C, Klein V, Tsogoeva SB and Efferth T. (2018). Treatment of multidrug-resistant leukemia cells by novel artemisinin-, egonol-, and thymoquinone-derived hybrid compoundsMolecules, 28: 841.

Heidelberger JB, Voigt A, Borisova ME, Petrosino G, Ruf S, Wagner SA and Beli P. (2018). Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc functionEMBO Rep, 19: e44754.

Mbaveng AT, Manekengb HT, Nguenangb GS, Dzotamb JK, Kuete V and Efferth T (2018). Cytotoxicity of 18 Cameroonian medicinal plants against drug sensitive and multi-factorial drug resistant cancer cellsJ Ethnopharmacology, 222: 21–33.

Mbaveng AT, Ndontsac BL, Kuete V, Nguekeuc YMM, Çelikd I, Mbouangouerec R, Tanec P and Efferth T. (2018). A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell deathPhytomedicine, 43: 78–85.

Özenver N, Saeed M, Ömur Demirezer L and Efferth T. (2018). Aloe-emodin as drug candidate for cancer therapyOncotarget, 9: 17770–17796

Roovers EF, Kaaij LJT, Redl S, Bronkhorst AW, Wiebrands K, de Jesus Domingues AM, Huang HY, Han CT, Riemer S, Dosch R, Salvenmoser W, Grün D, Butter F, van Oudenaarden A and Ketting RF. (2018). Tdrd6a regulates the aggregation of buc into functional subcellular compartments that drive germ cell specificationDev Cell, 46: 285–301.e9.

Wanke F, Tang Y, Gronke K, Klebow S, Moos S, Hauptmann J, Shanmugavadivu A, Regen T, Mufazalov IA, Gabriel LA, Reißig S, Diefenbach A, Kurschus FC and Waisman A. (2018). Expression of IL-17F is associated with non-pathogenic Th17 cellsJ Mol Med, 96: 819–829.


Van Acker A, Gronke K, Biswas A, Martens L, Saeys Y, Filtjens J, Taveirne S, Van Ammel E, Kerre T, Matthys P, Taghon T, Vandekerckhove B, Plum J, Dunay IR, Diefenbach A and Leclercq G. (2017). A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 propertiesCell Rep, 19: 1431–1443.

Dzama MM, Nigmatullina L, Sayols S, Kreim N and Soshnikova N. (2017). Distinct populations of embryonic epithelial progenitors generate Lgr5+ intestinal stem cellsDev Biol, 432: 258–264.

Kazakevych J, Sayols S, Messner B, Krienke C and Soshnikova N. (2017). Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cellsNucleic Acids Res, 45: 5770–5784.

Kuete V, Mbaveng AT, Sandjo LP, Zeino M and Efferth T. (2017). Cytotoxicity and mode of action of a naturally occurring naphthoquinone, 2-Acetyl-7-methoxynaphtho[2,3-B]furan-4,9-quinone towards multi-factorial drug-resistant cancer cellsPhytomedicine, 33: 62–68.

Nigmatullina L, Norkin M, Dzama MM, Messner B, Sayols S and Soshnikova N. (2017).  Id2 controls specification of Lgr5(+) intestinal stem cell progenitors during gut developmentEMBO J, 36: 869–885.


Kaymak A and Richly H. (2016). Zrf1 controls mesoderm lineage genes and cardiomyocyte differentiationCell Cycle, 15: 3306–3317.

Pataskar A, Jung J, Smialowski P, Noack F, Calegari F, Straub T and Tiwari VK. (2016). NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal programEMBO J, 35: 24-45


Kirmes I, Szczurek A, Prakash K, Charapitsa I, Heiser C, Musheev M, Schock F, Fornalczyk K, Ma D, Birk U, Cremer C and Reid G. (2015). A transient ischemic environment induces reversible compaction of chromatinGenome Biology, 16: 246.

Krieg B, Hirsch M, Scholz E, Nuhn L, Tabujew I, Bauer H, Decker S, Khobta A, Schmidt M, Tremel W, Zentel R, Peneva K, Koynov K, Mason AJ and Helm M. (2015). New techniques to assess in vitro release of siRNA from nanoscale polyplexesPharm Res, 32: 1957-74.

Sahu SK, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M and Tiwari V. (2015). JNK-dependent gene regulatory circuitry governs mesenchymal fateEMBO J, 34: 2162-2181.

Sakry D, Yigit H, Dimou L and Trotter J. (2015). Oligodendrocyte precursor cells synthesize neuromodulatory factorsPLoS One, 10: e0127222.

Stangenberg R, Wu Y, Hedrich J, Kurzbach D, Wehner D, Weidinger G, Kuan SL, Jansen MI, Jelezko F, Luh-mann HJ, Hinderberger D, Weil T and Müllen K. (2015). A polyphylene dendrimer drug transporter with precisely positioned amphiphilic surface patchesAdv Healthc Mater, 4: 377-84.

Wu CF and Efferth T. (2015). Miltirone induces G2/M cell cycle arrest and apoptosis in CCRF-CEM acute lymphoblastic leukemia cellsJ Nat Prod, 78: 1339-1347.

Zeino M, Brenk R, Gruber L, Zehl M, Urban E, Kopp B and Efferth T. (2015). Cytotoxicity of cardiotonic steroids in sensitive and multi-drug resistant leukemia cells and the link with Na+/K+-ATPaseJ Steroid Biochem, 150: 97-111.


Hamm R, Zeino M, Frewert S and Efferth T. (2014). Up-regulation of cholesterol associated genes as novel resistance mechanism in glioblastoma cells in response to archazolid BToxicol Appl Pharmacol, 281: 78-86.

Hamm R, Chen YR, Seo EJ, Zeino M, Wu CF, Müller R, Yang NS and Efferth T. (2014). Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cellsBiochemical Pharmacol, 91: 18-30.