2019

Aparisi Rey A, Karaulanov E, Sharopov S, Arab K, Schäfer A, Gierl M, Guggenhuber S, Brandes C, Pennella L, Gruhn WH, Jelinek R, Maul C, Conrad A, Kilb W, Luhmann HJ, Niehrs C and Lutz B (2019) Gadd45α modulates aversive learning through post‐transcriptional regulation of memory‐related mRNAs. EMBO Rep, 20:e46022 Link

Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I# and Niehrs C# (2019) GADD45A binds R-loops and recruits TET1 to CpG island promoters. Nat Genet, 51:217–223 (#indicates joint correspondence) Link

Colditz J, Thiele S, Baschant U, Garbe AI, Niehrs C, Hofbauer LC and Rauner M (2019) Osteogenic mediates glucocorticoid-induced but not arthritis-induced bone loss. J Bone Miner Res, 34:1314–1323 Link

Schüle KM*, Leichsenring M*, Andreani T, Vastolo V, Mallick M, Musheev MU, Karaulanov E and Niehrs C (2019) GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells. Genes Dev, 33:782–798 (*indicates joint contribution) Link

Tsourdi E, Colditz J, Lademann F, Rijntjes E, Köhrle J, Niehrs C, Hofbauer LC and Rauner M (2019) The role of Dickkopf-1 in thyroid hormone–induced changes of bone remodeling in male mice. Endocrinology, 160:664–674 Link

2018

Busceti CL, Di Menna L, Bianchi F, Mastroiacovo F, Di Pietro P, Traficante A, Bozza G, Niehrs C, Battaglia G, Bruno V, Fornai F, Volpe M, Rubattu S and Nicoletti F (2018) Dickkopf-3 causes neuroprotection by inducing vascular endothelial growth factor. Front Cell Neurosci, 12:292 Link

Colditz J, Thiele S, Baschant U, Niehrs C, Bonewald LF, Hofbauer LC and Rauner M (2018) Postnatal skeletal deletion of Dickkopf-1 increases bone formation and bone volume in male and female mice, despite Increased sclerostin expression. J Bone Miner Res, 33:1698–1707 Link

Dietrich K, Baumgart J, Eshkind L, Reuter L, Gödtel-Armbrust U, Butt E, Musheev M, Marini F, More P, Grosser T, Niehrs C, Wojnowski L and Mathäs M (2018) Health-Relevant phenotypes in the offspring of mice given CAR sctivators prior to pregnancy. Drug Metab Dispos, 46:1827–1835 Link

Karamariti E, Zhai C, Yu B, Qiao L, Wang Z, Potter CMF, Wong MM, Simpson RML, Zhang Z, Wang X, del Barco Barrantes I, Niehrs C, Kong D, Zhao Q, Zhang Y, Hu Y, Zhang C and Xu Q (2018) DKK3 (Dickkopf 3) alters atherosclerotic plaque phenotype involving vascular progenitor and fibroblast differentiation into smooth muscle cells. Arterioscler Thromb Vasc Biol, 38:425–437 Link

Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H and Scholl C (2018) Stk33 is required for spermatid differentiation and male fertility in mice. Dev Biol, 433:84–93 Link

Melnik S, Dvornikov D, Müller-Decker K, Depner S, Stannek P, Meister M, Warth A, Thomas M, Muley T, Risch A, Plass C, Klingmüller U, Niehrs C and Glinka A (2018) Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification. Cell Discov, 4:37 Link

Schäfer A, Mekker B, Mallick M, Vastolo V, Karaulanov E, Sebastian D, von der Lippen C, Epe B, Downes DJ, Scholz C and Niehrs C (2018) Impaired DNA demethylation of C/EBP sites causes premature aging. Genes Dev, 32:742–762 Link

Zhou L, Husted H, Moore T, Lu M, Deng D, Liu Y, Ramachandran V, Arumugam T, Niehrs C, Wang H, Chiao P, Ling J, Curran MA, Maitra A, Hung M-C, Lee JE, Logsdon CD and Hwang RF (2018) Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Sci Transl Med, 10:eaat3487 Link

2017

Berger BS, Acebron SP, Herbst J, Koch S and Niehrs C (2017) Parkinson’s disease-associated receptor GPR37 is an ER chaperone for LRP6. EMBO Rep, 18:712–725 Link

Kirsch N, Chang L-S, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM and Niehrs C (2017) Angiopoietin-like 4 is a Wnt signaling antagonist that promotes LRP6 turnover. Dev Cell, 43:71–82.e6 Link

Knuckles P, Carl SH, Musheev M, Niehrs C, Wenger A and Bühler M (2017) RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding. Nat Struct Mol Biol, 24:561–569 Link

Lelle M, Freidel C, Kaloyanova S, Tabujew I, Schramm A, Musheev M, Niehrs C, Müllen K and Peneva K (2017) Overcoming drug resistance by cell-penetrating peptide-mediated delivery of a doxorubicin dimer with high DNA-binding affinity. Eur J Med Chem, 130:336–345 Link

Schomacher L and Niehrs C (2017) DNA repair and erasure of 5-methylcytosine in vertebrates. BioEssays, 39:1600218 Link

Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C and Epe B (2017) Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes. DNA Repair, 58:13–20 Link

Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, del Barco Barrantes I, Niehrs C, Schett G, Hu Y, Wang W, Willeit J, Qu A and Xu Q (2017) A cytokine-like protein dickkopf-related protein 3 is atheroprotective. Circulation, 136:1022–1036 Link

2016

Acebron SP and Niehrs C (2016) β-catenin-independent roles of Wnt/LRP6 signaling. Trends Cell Biol, 26:956–967 Link

Boutros M and Niehrs C (2016) Sticking around: Short-range activity of Wnt ligands. Dev Cell, 36:485–486 Link

Kaaij LJT, Mokry M, Zhou M, Musheev M, Geeven G, Melquiond ASJ, de Jesus Domingues AM, de Laat W, Niehrs C, Smith AD and Ketting RF (2016) Enhancers reside in a unique epigenetic environment during early zebrafish development. Genome Biol, 17:146 Link

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C and Augustin HG (2016) Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+ /NFAT signaling. Dev Cell, 36:79–93 Link

Schomacher L, Han D, Musheev MU, Arab K, Kienhofer S, von Seggern A and Niehrs C (2016) Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation. Nat Struct Mol Biol, 23:116–124 Link

2015

Blum M, De Robertis EM, Wallingford JB and Niehrs C (2015) Morpholinos: Antisense and sensibility. Dev Cell, 35:145–149 Link

Fukusumi Y, Meier F, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, Wurst W and Prakash N (2015) Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse. J Neurosci, 35:13385–13401 Link

Huang Y-L, Anvarian Z, Döderlein G, Acebron SP and Niehrs C (2015) Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis. Proc Natl Acad Sci USA, 112:5732–5737 Link

Kienhöfer S, Musheev MU, Stapf U, Helm M, Schomacher L, Niehrs C and Schäfer A (2015) GADD45a physically and functionally interacts with TET1. Differentiation, 90:59–68 Link

Kimura-Yoshida C, Mochida K, Ellwanger K, Niehrs C and Matsuo I (2015) Fate specification of neural plate border by canonical Wnt signaling and Grhl3 is crucial for neural tube closure. EBioMedicine, 2:513–527 Link

Koch S, Acebron SP, Herbst J, Hatiboglu G and Niehrs C (2015) Post-transcriptional Wnt signaling governs epididymal sperm maturation. Cell, 163:1225–1236 Link

Lelle M, Kaloyanova S, Freidel C, Theodoropoulou M, Musheev M, Niehrs C, Stalla G and Peneva K (2015) Octreotide-mediated tumor-targeted drug delivery via a cleavable doxorubicin–peptide conjugate. Mol Pharm, 12:4290–4300 Link

Welling M, Chen H-H, Munoz J, Musheev MU, Kester L, Junker JP, Mischerikow N, Arbab M, Kuijk E, Silberstein L, Kharchenko P V., Geens M, Niehrs C, van de Velde H, van Oudenaarden A, Heck AJ and Geijsen N (2015) DAZL regulates Tet1 translation in murine embryonic stem cells. EMBO Rep, 16:791–802 Link

2014

Acebron SP, Karaulanov E, Berger BS, Huang YL and Niehrs C (2014) Mitotic Wnt signaling promotes protein stabilization and regulates cell size. Mol Cell, 54:663–674 Link

Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I#, Niehrs C# and Plass C# (2014) Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A. Mol Cell, 55:604–614 (#indicates joint correspondence) Link

Davidson G and Niehrs C (2014) Wnt Signaling at the Membrane. Pages 15–32 in: Wnt Signaling in Development and Disease (eds. Hoppler S & Moon RT), Wiley, Hoboken  Link

De Robertis EM and Niehrs C (2014) Herbert Steinbeisser: A life with the Xenopus embryo. Int J Dev Biol, 58:299–302 Link

Huang YL and Niehrs C (2014) Polarized Wnt signaling regulates ectodermal cell fate in Xenopus. Dev Cell, 29:250–257 Link

Niehrs C (2014) Chromatin dynamics and stem cells. Pages 445–450 in: Jahrbuch 2013 der Deutschen Akademie der Naturforscher Leopoldina (ed. Hacker J), Leopoldina, Halle  Link

Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P and Kuner R (2014) Wnt-fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways. Neuron, 83:104–121 Link

2013

Cruciat C-M and Niehrs C (2013) Secreted and transmembrane Wnt inhibitors and activators. Cold Spring Harb Perspect Biol, 5:a015081 Link

Cruciat CM, Dolde C, de Groot REA, Ohkawara B, Reinhard C, Korswagen HC and Niehrs C (2013) RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling. Science, 339:1436–1441 Link

Demir K, Kirsch N, Beretta CA, Erdmann G, Ingelfinger D, Moro E, Argenton F, Carl M, Niehrs C and Boutros M (2013) RAB8B is required for activity and caveolar endocytosis of LRP6. Cell Rep, 4:1224–1234 Link

Niehrs C (2013) DNA demethylation, repair and beyond. Pages 387–392 in: Jahrbuch 2012 der Deutschen Akademie der Naturforscher Leopoldina (ed. Hacker J), Leopoldina, Halle  Link

Romero D, Kawano Y, Bengoa N, Walker MM, Maltry N, Niehrs C, Waxman J and Kypta R (2013) Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling. J Cell Sci, 126:1858–1867 Link

Schäfer A, Karaulanov E, Stapf U, Döderlein G and Niehrs C (2013) Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3. Genes Dev, 27:261–273 Link

Seib DRM, Corsini NS, Ellwanger K, Plaas C, Mateos A, Pitzer C, Niehrs C, Celikel T and Martin-Villalba A (2013) Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline. Cell Stem Cell, 12:204–214 Link

2012

El Wakil A, Bandulik S, Guy N, Bendahhou S, Zennaro M-C, Niehrs C, Mari B, Warth R, Barhanin J and Lalli E (2012) Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex. Hum Mol Genet, 21:4922–4929 Link

Gierl MS, Gruhn WH, von Seggern A, Maltry N and Niehrs C (2012) GADD45G functions in male sex determination by promoting p38 signaling and sry expression. Dev Cell, 23:1032–1042 Link

Kawano Y, Romero D, Bengoa N, Maltry N, Walker M, Eto M, Waxman J, Niehrs N and Kypra R (2012) Crucial role of Dickkopf-3 in prostate morphogenesis in vitro and in vivo. Eur Urol Suppl, 11:e654–e654a Link

Niehrs C (2012) The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol, 13:767–779 Link

Niehrs C and Acebron SP (2012) Mitotic and mitogenic Wnt signalling. EMBO J, 31:2705–2713 Link

Niehrs C and Schäfer A (2012) Active DNA demethylation by Gadd45 and DNA repair. Trends Cell Biol, 22:220–227 Link

Papatriantafyllou M, Moldenhauer G, Ludwig J, Tafuri A, Garbi N, Hollmann G, Küblbeck G, Klevenz A, Schmitt S, Pougialis G, Niehrs C, Gröne H-J, Hammerling GJ, Arnold B and Oelert T (2012) Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance. Proc Natl Acad Sci USA, 109:1631–1636 Link

Teufel A, Becker D, Weber SN, Dooley S, Breitkopf-Heinlein K, Maass T, Hochrath K, Krupp M, Marquardt JU, Kolb M, Korn B, Niehrs C, Zimmermann T, Godoy P, Galle PR and Lammert F (2012) Identification of RARRES1 as a core regulator in liver fibrosis. J Mol Med, 90:1439–1447 Link

2011

Glinka A, Dolde C, Kirsch N, Huang Y-L, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat C-M and Niehrs C (2011) LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep, 12:1055–1061 Link

Huhn S, Ingelfinger D, Bermejo JL, Bevier M, Pardini B, Naccarati A, Steinke V, Rahner N, Holinski-Feder E, Morak M, Schackert HK, Görgens H, Pox CP, Goecke T, Kloor M, Loeffler M, Büttner R, Vodickova L, Novotny J, Demir K, Cruciat C-M, Renneberg R, Huber W, Niehrs C, Boutros M, Propping P, Vodièka P, Hemminki K and Försti A (2011) Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications. Int J Mol Epidemiol Genet, 2:36–50 Link

Kaufmann LT, Gierl MS and Niehrs C (2011) Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development. Gene Expr Patterns, 11:465–470 Link

Kaufmann LT and Niehrs C (2011) Gadd45a and Gadd45g regulate neural development and exit from pluripotency in Xenopus. Mech Dev, 128:401–411 Link

Liang J, Fu Y, Cruciat C-M, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C and Wu W (2011) Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. Mol Cell Biol, 31:2577–2590 Link

Niehrs C (2011) Dialectics, systems biology and embryonic induction. Differentiation, 81:209–216 Link

Ohkawara B, Glinka A and Niehrs C (2011) Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. Dev Cell, 20:303–314 Link

Ohkawara B and Niehrs C (2011) An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos. Dev Dyn, 240:188–194 Link

Paulsen M*, Legewie S*, Eils R, Karaulanov E and Niehrs C (2011) Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci USA, 108:10202–10207 (Editors' Choice in Science 333, 138, *indicates joint contribution) Link

Pietilä I, Ellwanger K, Railo A, Jokela T, Barrantes I del B, Shan J, Niehrs C and Vainio SJ (2011) Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling. Dev Biol, 353:50–60 Link

Ribeiro D, Ellwanger K, Glagow D, Theofilopoulos S, Corsini NS, Martin-Villalba A, Niehrs C and Arenas E (2011) Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis. PLOS One, 6:e15786 Link

Rousso SZ, Schyr RB-H, Gur M, Zouela N, Kot-Leibovich H, Shabtai Y, Koutsi-Urshanski N, Baldessari D, Pillemer G, Niehrs C and Fainsod A (2011) Negative autoregulation of Oct3/4 through Cdx1 promotes the onset of gastrulation. Dev Dyn, 240:796–807 Link

Sytnikova YA, Kubarenko A V., Schäfer A, Weber ANR and Niehrs C (2011) Gadd45a is an RNA binding protein and is localized in nuclear speckles. PLOS One, 6:e14500 Link

2010

Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, Niehrs C and Boutros M (2010) Wnt/frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr Biol, 20:1263–1268 Link

Cruciat C-M, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, Ingelfinger D, Boutros M and Niehrs C (2010) Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science, 327:459–463 Link

Davidson G and Niehrs C (2010) Emerging links between CDK cell cycle regulators and Wnt signaling. Trends Cell Biol, 20:453–460 Link

Niehrs C (2010) On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes. Development, 137:845–857 Link

Niehrs C and Acebron SP (2010) Wnt signaling: Multivesicular bodies hold GSK3 captive. Cell, 143:1044–1046 Link

Niehrs C and Boutros M (2010) Trafficking, acidification, and growth factor signaling. Sci Signal, 3:pe26 Link

Niehrs C and Shen J (2010) Regulation of Lrp6 phosphorylation. Cell Mol Life Sci, 67:2551–2562 Link

Schäfer A, Schomacher L, Barreto G, Döderlein G and Niehrs C (2010) Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation. PLOS One, 5:e14060 Link

Schulze J, Seitz S, Saito H, Schneebauer M, Marshall RP, Baranowsky A, Busse B, Schilling AF, Friedrich FW, Albers J, Spiro AS, Zustin J, Streichert T, Ellwanger K, Niehrs C, Amling M, Baron R and Schinke T (2010) Negative regulation of bone formation by the transmembrane Wnt antagonist kremen-2. PLOS One, 5:e10309 Link

Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen Y-G and Wu W (2010) Xenopus Skip modulates Wnt/β-catenin signaling and functions in neural crest induction. J Biol Chem, 285:10890–10901 Link

2009

Davidson G, Shen J, Huang Y-L, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M and Niehrs C (2009) Cell cycle control of Wnt receptor activation. Dev Cell, 17:788–799 Link

Karaulanov E, Böttcher RT, Stannek P, Wu W, Rau M, Ogata S, Cho KWY and Niehrs C (2009) Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos. PLOS One, 4:e5742 Link

Niehrs C (2009) Dialektik der Embryonalen induktion. Pages 42–62 in: Jahrbuch der Heidelberger Akademie der Wissenschaft für 2008 Heidelberger Akademie der Wissenschaft, Heidelberg  Link

Niehrs C (2009) Active DNA demethylation and DNA repair. Differentiation, 77:1–11 Link

2008

Ellwanger K, Saito H, Clement-Lacroix P, Maltry N, Niedermeyer J, Lee WK, Baron R, Rawadi G, Westphal H and Niehrs C (2008) Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol, 28:4875–4882 Link

Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG and Niehrs C (2008) The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development, 135:3655–3664 Link

2007

Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, Döderlein G, Maltry N, Wu W, Lyko F and Niehrs C (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature, 445:671–675 Link

Bilic J, Huang Y-L, Davidson G, Zimmermann T, Cruciat C-M, Bienz M and Niehrs C (2007) Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science, 316:1619–1622 Link

Caneparo L, Huang Y-L, Staudt N, Tada M, Ahrendt R, Kazanskaya O, Niehrs C and Houart C (2007) Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/betacatenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes Dev, 21:465–480 Link

Carmona-Fontaine C, Acuña G, Ellwanger K, Niehrs C and Mayor R (2007) Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm. Dev Biol, 309:208–221 Link

Hassler C, Cruciat C-M, Huang Y-L, Kuriyama S, Mayor R and Niehrs C (2007) Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling. Development, 134:4255–4263 Link

Ogata S, Morokuma J, Hayata T, Kolle G, Niehrs C, Ueno N and Cho KWY (2007) TGF-beta signaling-mediated morphogenesis: Modulation of cell adhesion via cadherin endocytosis. Genes Dev, 21:1817–1831 Link

Pinho S and Niehrs C (2007) Dkk3 is required for TGF-β signaling during Xenopus mesoderm induction. Differentiation, 75:957–967 Link