Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I# and Niehrs C#. (2019). GADD45A binds R-loops and recruits TET1 to CpG island promoters. Nat Genet, 51: 217–223. (#indicates joint correspondence) Link

Tsourdi E, Colditz J, Lademann F, Rijntjes E, Köhrle J, Niehrs C, Hofbauer LC and Rauner M. (2019). The role of Dickkopf-1 in thyroid hormone-induced changes of bone remodeling in male mice. Endocrinology,  doi: 10.1210/en.2018-00998. Link


Busceti CL, Di Menna L, Bianchi F, Mastroiacovo F, Di Pietro P, Traficante A, Bozza G, Niehrs C, Battaglia G, Bruno V, Fornai F, Volpe M, Rubattu S and Nicoletti F. (2018). Dickkopf-3 causes neuroprotection by inducing vascular endothelial growth factor. Front Cell Neurosci, 12: 292. Link

Colditz J, Thiele S, Baschant U, Niehrs C, Bonewald LF, Hofbauer LC and Rauner M. (2018). Postnatal skeletal deletion of Dickkopf-1 increases bone formation and bone volume in male and female mice, despite increased sclerostin expression. J Bone Miner Res, 33: 1698–1707. Link

Dietrich K, Baumgart J, Eshkind L, Reuter L, Gödtel-Armbrust U, Butt E, Musheev M, Marini F, More P, Grosser T, Niehrs C, Wojnowski L and Mathäs M. (2018). Health-relevant phenotypes in the offspring of mice given CAR sctivators prior to pregnancy. Drug Metab Dispos, 46: 1827–1835. Link

Karamariti E, Zhai C, Yu B, Qiao L, Wang Z, Potter CMF, Wong MM, Simpson RML, Zhang Z, Wang X, del Barco Barrantes I, Niehrs C, Kong D, Zhao Q, Zhang Y, Hu Y, Zhang C and Xu Q. (2018). DKK3 (Dickkopf 3) alters atherosclerotic plaque phenotype involving vascular progenitor and fibroblast differentiation into smooth muscle cells. Arterioscler Thromb Vasc Biol, 38: 425–437. Link

Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H and Scholl C. (2018).  Stk33 is required for spermatid differentiation and male fertility in mice. Dev Biol, 433: 84–93. Link

Melnik S, Dvornikov D, Müller-Decker K, Depner S, Stannek P, Meister M, Warth A, Thomas M, Muley T, Risch A, Plass C, Klingmüller U, Niehrs C and Glinka A. (2018). Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification. Cell Discov, 4: 37. Link

Schäfer A, Mekker B, Mallick M, Vastolo V, Karaulanov E, Sebastian D, von der Lippen C, Epe B, Downes DJ, Scholz C and Niehrs C. (2018). Impaired DNA demethylation of C/EBP sites causes premature aging. Genes Dev, 32: 742–762. Link

Zhou L, Husted H, Moore T, Lu M, Deng D, Liu Y, Ramachandran V, Arumugam T, Niehrs C, Wang H, Chiao P, Ling J, Curran MA, Maitra A, Hung MC, Lee JE, Logsdon CD and Hwang RF. (2018). Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Sci Transl Med, 10: eaat3487. Link


Berger BS, Acebron SP, Herbst J, Koch S and Niehrs C. (2017). Parkinson’s disease-associated receptor GPR37 is an ER chaperone for LRP6. EMBO Rep, 18: 712–725. Link

Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM and Niehrs C. (2017). Angiopoietin-like 4 is a Wnt signaling antagonist that promotes LRP6 turnover. Dev Cell, 43: 71–82.e6. Link

Knuckles P, Carl SH, Musheev M, Niehrs C, Wenger A and Bühler M. (2017). RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding. Nat Struct Mol Biol, 24: 561–569. Link

Lelle M, Freidel C, Kaloyanova S, Tabujew I, Schramm A, Musheev M, Niehrs C, Müllen K and Peneva K. (2017). Overcoming drug resistance by cell-penetrating peptide-mediated delivery of a doxorubicin dimer with high DNA-binding affinity. Eur J Med Chem, 130: 336–345. Link

Schomacher L and Niehrs C. (2017). DNA repair and erasure of 5-methylcytosine in vertebrates. BioEssays, 39: 1600218. Link

Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C and Epe B. (2017). Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes. DNA Repair (Amst), 58: 13–20. Link

Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, del Barco Barrantes I, Niehrs C, Schett G, Hu Y, Wang W, Willeit J, Qu A and Xu Q. (2017). A cytokine-like protein dickkopf-related protein 3 is atheroprotective. Circulation, 136: 1022–1036. Link


Acebron SP and Niehrs C. (2016). β-catenin-independent roles of Wnt/LRP6 signaling. Trends Cell Biol, 26: 956–967. Link

Boutros M and Niehrs C. (2016). Sticking around: Short-range activity of Wnt ligands. Dev Cell, 36: 485–486. Link

Kaaij LJT, Mokry M, Zhou M, Musheev M, Geeven G, Melquiond ASJ, de Jesus Domingues AM, de Laat W, Niehrs C, Smith AD and Ketting RF. (2016). Enhancers reside in a unique epigenetic environment during early zebrafish development. Genome Biol, 17: 146. Link

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C and Augustin HG. (2016). Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+ /NFAT signaling. Dev Cell, 36: 79–93. Link

Schomacher L, Han D, Musheev MU, Arab K, Kienhofer S, von Seggern A and Niehrs C. (2016). Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation. Nat Struct Mol Biol, 23: 116–124. Link


Blum M, De Robertis EM, Wallingford JB and Niehrs C. (2015). Morpholinos: Antisense and sensibility. Dev Cell, 35: 145–149. Link

Fukusumi Y, Meier F, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, Wurst W and Prakash N. (2015). Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse. J Neurosci, 35: 13385–13401. Link

Huang YL, Anvarian Z, Döderlein G, Acebron SP and Niehrs C. (2015). Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis. Proc Natl Acad Sci USA, 112: 5732–5737. Link

Kienhöfer S, Musheev MU, Stapf U, Helm M, Schomacher L, Niehrs C and Schäfer A. (2015). GADD45a physically and functionally interacts with TET1. Differentiation, 90: 59–68. Link

Kimura-Yoshida C, Mochida K, Ellwanger K, Niehrs C and Matsuo I. (2015). Fate specification of neural plate border by canonical Wnt signaling and Grhl3 is crucial for neural tube closure. EBioMedicine, 2: 513–527. Link

Koch S, Acebron SP, Herbst J, Hatiboglu G and Niehrs C. (2015). Post-transcriptional Wnt signaling governs epididymal sperm maturation. Cell, 163: 1225–1236. Link

Lelle M, Kaloyanova S, Freidel C, Theodoropoulou M, Musheev M, Niehrs C, Stalla G and Peneva K. (2015). Octreotide-mediated tumor-targeted drug delivery via a cleavable doxorubicin–peptide conjugate. Mol Pharm, 12: 4290–4300. Link

Welling M, Chen HH, Munoz J, Musheev MU, Kester L, Junker JP, Mischerikow N, Arbab M, Kuijk E, Silberstein L, Kharchenko PV, Geens M, Niehrs C, van de Velde H, van Oudenaarden A, Heck AJ and Geijsen N. (2015). DAZL regulates Tet1 translation in murine embryonic stem cells. EMBO Rep, 16: 791–802. Link


Acebron SP, Karaulanov E, Berger BS, Huang YL and Niehrs C. (2014). Mitotic Wnt signaling promotes protein stabilization and regulates cell size. Mol Cell, 54: 663–674. Link

Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I#, Niehrs C# and Plass C#. (2014). Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A. Mol Cell, 55: 604–614. (#indicates joint correspondence) Link

Davidson G and Niehrs C (2014). Wnt Signaling at the Membrane. Pages 15–32, In: Wnt signaling in development and disease: Molecular mechanisms and biological functions. Hoppler S and Moon RT (ed). Wiley Blackwell, Hoboken. Link

De Robertis EM and Niehrs C. (2014). Herbert Steinbeisser: A life with the Xenopus embryo. Int J Dev Biol, 58: 299–302. Link

Huang YL and Niehrs C. (2014). Polarized Wnt signaling regulates ectodermal cell fate in Xenopus. Dev Cell, 29: 250–257. Link

Niehrs C. (2014). Chromatin dynamics and stem cells. pages 445–449, In: Jahrbuch 2013 der deutschen Akademie der Naturforscher Leopoldina. Hacker J (ed). Leopoldina, Halle (Saale).  Link

Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P and Kuner R. (2014). Wnt-fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways. Neuron, 83: 104–121. Link


Cruciat CM, Dolde C, de Groot REA, Ohkawara B, Reinhard C, Korswagen HC and Niehrs C. (2013). RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling. Science, 339: 1436–1441. Link

Cruciat CM and Niehrs C. (2013). Secreted and transmembrane Wnt inhibitors and activators. Cold Spring Harb Perspect Biol, 5: a015081. Link

Demir K, Kirsch N, Beretta CA, Erdmann G, Ingelfinger D, Moro E, Argenton F, Carl M, Niehrs C and Boutros M. (2013). RAB8B is required for activity and caveolar endocytosis of LRP6. Cell Rep, 4: 1224–1234. Link

Niehrs C (2013). DNA demethylation, repair and beyond. pages 387–391, In: Jahrbuch 2012 der deutschen Akademie der Naturforscher Leopoldina. Jahrgang 58. Hacker J (ed). Leopoldina, Halle(Saale). Link

Romero D, Kawano Y, Bengoa N, Walker MM, Maltry N, Niehrs C, Waxman J and Kypta R. (2013). Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling. J Cell Sci, 126: 1858–1867. Link

Schäfer A, Karaulanov E, Stapf U, Döderlein G and Niehrs C. (2013). Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3. Genes Dev, 27: 261–273. Link

Seib DRM, Corsini NS, Ellwanger K, Plaas C, Mateos A, Pitzer C, Niehrs C, Celikel T and Martin-Villalba A. (2013). Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline. Cell Stem Cell, 12: 204–214. Link


El Wakil A, Bandulik S, Guy N, Bendahhou S, Zennaro MC, Niehrs C, Mari B, Warth R, Barhanin J and Lalli E. (2012). Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex. Hum Mol Genet, 21: 4922–4929. Link

Gierl MS, Gruhn WH, von Seggern A, Maltry N and Niehrs C. (2012). GADD45G functions in male sex determination by promoting p38 signaling and sry expression. Dev Cell, 23: 1032–1042. Link

Kawano Y, Romero D, Bengoa N, Maltry N, Walker M, Eto M, Waxman J, Niehrs N and Kypra R. (2012). Crucial role of Dickkopf-3 in prostate morphogenesis in vitro and in vivo. Eur Urol Suppl, 11: e654–e654a. Link

Niehrs C and Schäfer A. (2012). Active DNA demethylation by Gadd45 and DNA repair. Trends Cell Biol, 22: 220–227. Link

Niehrs C and Acebron SP. (2012). Mitotic and mitogenic Wnt signalling. EMBO J, 31: 2705–2713. Link

Niehrs C. (2012). The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol, 13: 767–779. Link

Papatriantafyllou M, Moldenhauer G, Ludwig J, Tafuri A, Garbi N, Hollmann G, Küblbeck G, Klevenz A, Schmitt S, Pougialis G, Niehrs C, Gröne HJ, Hammerling GJ, Arnold B and Oelert T. (2012). Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance. Proc Natl Acad Sci USA, 109: 1631–1636. Link

Teufel A, Becker D, Weber SN, Dooley S, Breitkopf-Heinlein K, Maass T, Hochrath K, Krupp M, Marquardt JU, Kolb M, Korn B, Niehrs C, Zimmermann T, Godoy P, Galle PR and Lammert F. (2012). Identification of RARRES1 as a core regulator in liver fibrosis. J Mol Med, 90: 1439–1447. Link


Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat C-M and Niehrs C. (2011). LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep, 12: 1055–1061. Link

Huhn S, Ingelfinger D, Bermejo JL, Bevier M, Pardini B, Naccarati A, Steinke V, Rahner N, Holinski-Feder E, Morak M, Schackert HK, Görgens H, Pox CP, Goecke T, Kloor M, Loeffler M, Büttner R, Vodickova L, Novotny J, Demir K, Cruciat CM, Renneberg R, Huber W, Niehrs C, Boutros M, Propping P, Vodièka P, Hemminki K and Försti A. (2011). Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications. Int J Mol Epidemiol Genet, 2: 36–50. Link

Kaufmann LT and Niehrs C. (2011). Gadd45a and Gadd45g regulate neural development and exit from pluripotency in Xenopus. Mech Dev, 128: 401–411. Link

Kaufmann LT, Gierl MS and Niehrs C. (2011). Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development. Gene Expr Patterns, 11: 465–470. Link

Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C and Wu W. (2011). Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. Mol Cell Biol, 31: 2577–2590. Link

Niehrs C. (2011). Dialectics, systems biology and embryonic induction. Differentiation, 81: 209–216. Link

Ohkawara B and Niehrs C. (2011). An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos. Dev Dyn, 240: 188–194. Link

Ohkawara B, Glinka A and Niehrs C. (2011). Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. Dev Cell, 20: 303–314. Link

Paulsen M*, Legewie S*, Eils R, Karaulanov E and Niehrs C. (2011). Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci USA, 108: 10202–10207. (Editors' Choice in Science 333, 138). (*indicates joint contribution) Link

Pietilä I, Ellwanger K, Railo A, Jokela T, Barrantes I del B, Shan J, Niehrs C and Vainio SJ. (2011). Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling. Dev Biol, 353: 50–60. Link

Ribeiro D, Ellwanger K, Glagow D, Theofilopoulos S, Corsini NS, Martin-Villalba A, Niehrs C and Arenas E. (2011). Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis. PLoS One, 6: e15786. Link

Rousso SZ, Schyr RBH, Gur M, Zouela N, Kot-Leibovich H, Shabtai Y, Koutsi-Urshanski N, Baldessari D, Pillemer G, Niehrs C and Fainsod A. (2011). Negative autoregulation of Oct3/4 through Cdx1 promotes the onset of gastrulation. Dev Dyn, 240: 796–807. Link

Sytnikova YA, Kubarenko AV, Schäfer A, Weber ANR and Niehrs C. (2011). Gadd45a is an RNA binding protein and is localized in nuclear speckles. PLoS One, 6: e14500. Link


Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, Niehrs C and Boutros M. (2010). Wnt/frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr Biol, 20: 1263–1268. Link

Cruciat CM, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, Ingelfinger D, Boutros M and Niehrs C. (2010). Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science, 327: 459–463. Link

Davidson G and Niehrs C. (2010). Emerging links between CDK cell cycle regulators and Wnt signaling. Trends Cell Biol, 20: 453–460. Link

Niehrs C. (2010). On growth and form: A cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes. Development, 137: 845–857. Link

Niehrs C and Shen J. (2010). Regulation of Lrp6 phosphorylation. Cell Mol Life Sci, 67: 2551–2562. Link

Niehrs C and Boutros M. (2010). Trafficking, acidification, and growth factor signaling. Sci Signal, 3: pe26. Link

Niehrs C and Acebron SP. (2010). Wnt signaling: Multivesicular bodies hold GSK3 captive. Cell, 143: 1044–1046. Link

Schäfer A, Schomacher L, Barreto G, Döderlein G and Niehrs C. (2010). Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation. PLoS One, 5: e14060. Link

Schulze J, Seitz S, Saito H, Schneebauer M, Marshall RP, Baranowsky A, Busse B, Schilling AF, Friedrich FW, Albers J, Spiro AS, Zustin J, Streichert T, Ellwanger K, Niehrs C, Amling M, Baron R and Schinke T. (2010). Negative regulation of bone formation by the transmembrane Wnt antagonist kremen-2. PLoS One, 5: e10309. Link

Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG and Wu W. (2010). Xenopus Skip modulates Wnt/β-catenin signaling and functions in neural crest induction. J Biol Chem, 285: 10890–10901. Link


Davidson G, Shen J, Huang YL, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M and Niehrs C. (2009). Cell cycle control of Wnt receptor activation. Dev Cell, 17: 788–799. Link

Karaulanov E, Böttcher RT, Stannek P, Wu W, Rau M, Ogata S, Cho KWY and Niehrs C. (2009). Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos. PLoS One, 4: e5742. Link

Niehrs C. (2009). Active DNA demethylation and DNA repair. Differentiation, 77: 1–11. Link

Niehrs C. (2009). Dialektik der embryonalen Induktion. pages 42–61, In: Jahrbuch der heidelberger Akademie der Wissenschaft für 2008. Heidelberger Akademie der Wissenschaft, Heidelberg.


Ellwanger K, Saito H, Clement-Lacroix P, Maltry N, Niedermeyer J, Lee WK, Baron R, Rawadi G, Westphal H and Niehrs C. (2008). Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol, 28: 4875–4882. Link

Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG and Niehrs C. (2008). The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development, 135: 3655–3664. Link


Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M and Niehrs C. (2007). Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science, 316: 1619–1622. Link

Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, Döderlein G, Maltry N, Wu W, Lyko F and Niehrs C. (2007). Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature, 445: 671–675. Link

Caneparo L, Huang YL, Staudt N, Tada M, Ahrendt R, Kazanskaya O, Niehrs C and Houart C. (2007). Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/betacatenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes Dev, 21: 465–480. Link

Carmona-Fontaine C, Acuña G, Ellwanger K, Niehrs C and Mayor R. (2007). Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm. Dev Biol, 309: 208–221. Link

Hassler C, Cruciat CM, Huang YL, Kuriyama S, Mayor R and Niehrs C. (2007). Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling. Development, 134: 4255–4263. Link

Ogata S, Morokuma J, Hayata T, Kolle G, Niehrs C, Ueno N and Cho KWY. (2007). TGF-beta signaling-mediated morphogenesis: Modulation of cell adhesion via cadherin endocytosis. Genes Dev, 21: 1817–1831. Link

Pinho S and Niehrs C. (2007). Dkk3 is required for TGF-β signaling during Xenopus mesoderm induction. Differentiation, 75: 957–967. Link