Coagulation signaling in innate immunity

The hemostatic system is comprised of the coagulation and fibrinolytic protease cascades and supports inflammatory and immune reactions during infection and tissue injury. We are broadly interested in understanding the cellular and molecular connections between coagulation and inflammation. This includes understanding how inflammatory processes contribute to the initiation of coagulation, the roles of tissue factor and coagulation protease signalling networks in the integration and modulation of inflammatory stimuli in immune cells, and how macrophage phenotypes are controlled by coagulation proteases in chronic inflammation. We investigate these questions using a combination genetic, transcriptional and proteomics tools.

Research website

Position

Since 2014: Scientific Director CTH Mainz
Since 2013: Alexander von Humboldt Professor, CTH Mainz
Since 2007: Margaret Thatcher Professor of Biological Chemistry, Thrombosis Research Institute, London, U.K. (external affiliation)
Since 2005: Professor of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA
1992-2005: Assistant to Associate Professor, The Scripps Research Institute
1990-1992: Senior Research Associate, The Scripps Research Institute
1988-1990: DFG Exchange Visitor, Department of Immunology, Scripps Clinic
1987-1988: Research Associate, Max-Planck Society

Education

1987: Dr. med. (summa cum laude) Justus-Liebig University, Giessen; Advisor: Prof. Müller-Berghaus, Max-Planck Society
1984-1986: Doctoral Fellowship, Max-Planck Society
1977-1984: Medicine, Justus-Liebig University, Giessen

 

Selected publications by Wolfram Ruf

  1. Rothmeier AS, Versteeg HH, Ruf W (2019) Factor VIIa-induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells. J Thromb Haemost, 17(4):627-634 Link

  2. Müller-Calleja N, Ritter S, Hollerbach A, Falter T, Lackner KJ, Ruf W (2018) Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodiesBlood Adv, 2(9):979-986 Link

  3. Rothmeier AS, Liu E, Chakrabarty S, Disse J, Mueller BM, Ostergaard H, Ruf W (2018) Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signalingBlood, 131(6):674-685 Link

Nguyen TS, Lapidot T, Ruf W (2018) Extravascular coagulation in hematopoietic stem and progenitor cell regulationBlood, 132(2):123-131 Link

Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W (2017) Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus developmentBlood, 129: 2291-2302 Link