Cell biology of genome maintenance

Positions held

  • Since 2015: Group Leader, Institute of Molecular Biology (IMB), Mainz
  • 2013-2014: Research Fellow, National Cancer Institute, National Institutes of Health, USA
  • 2008-2013: Postdoc, National Cancer Institute, National Institutes of Health, USA


  • 2008: PhD in Molecular Biology and Cytogenetics, Medical School, University of Patras
  • 2005: MSc in Applications in Medical Sciences, Medical School, University of Patras
  • 2002: Diploma in Biology, University of Patras

Recent publications by Vassilis Roukos

Gothe HJ, Minneker V, Roukos V. (2018). Dynamics of Double-Strand Breaks: Implications for the Formation of Chromosome Translocations (2018) Adv. Exp. Med. Biol. 1044:27-38

Zirkel A, Nikolic M, Sofiadis K, Mallm JP, Brackley CA, Gothe H, Drechsel O, Becker C, Altmüller J, Josipovic N, Georgomanolis T, Brant L, Franzen J, Koker M, Gusmao EG, Costa IG, Ullrich RT, Wagner W, Roukos V, Nürnberg P, Marenduzzo D, Rippe K, Papantonis A (2018). HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types. Mol Cell, 70(4), 730-744

Dörsam B, Seiwert N, Foersch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M, Stier A, Mangerich A, Dantzer F, Kaina B, Fahrer J. (2018) PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.Proc Natl Acad Sci U S A, Apr 24;115 (17): 4061-4070

Roukos V. Actin proteins assemble to protect the genome (2018). Nature, 559 (7712): 35-37

Piccino R, Cipinska M and Roukos V (2017). Studies of the DNA damage response by using the Lac operator/repressor (LacO/LacR) tethering system.Methods Cell Biol, 1599: 263-275

Research website