Kinetic modelling of alternative splicing decisions

Stefan Legewie

Positions held

  • Since 2010: Group Leader, Institute of Molecular Biology (IMB), Mainz
  • 2009-2010: Group Leader ‘Theoretical Systems Biology’, Department of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg
  • 2008-2009: Postdoctoral Researcher, Institute for Theoretical Biology, Humboldt University Berlin

Education

  • 2008: PhD in Biophysics, Humboldt University, Berlin
  • 2004: Diploma in Biochemistry, University of Witten/Herdecke

Recent publications by Stefan Legewie

Becker K, Bluhm A*, Casas-Vila N*, Dinges N*, Dejung M, Sayols S, Kreutz C, Roignant JY, Butter F# and Legewie S# (2018). Quantifying post-transcriptional regulation in the development of Drosophila melanogaster. Nat Commun, 9: 4970

Braun S*, Enculescu M*, Setty ST*, Cortés-López M, de Almeida BP, Sutandy FXR, Schulz L, Busch A, Seiler M, Ebersberger S, Barbosa-Morais NL, Legewie S#, König J# and Zarnack K# (2018). Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis. Nat Commun, 9: 3315

Sutandy R*, Ebersberger S*, Huang L*, Busch A, Bach M, Kang HS, Fallmann J, Maticzka D, Backofen R, Stadler PF, Zarnack K, Sattler M, Legewie S#, Koenig J# (2018). In vitro iCLIP-based modeling uncovers how the splicing factor U2AF65 relies on regulation by co-factors. Genome Res, 28(5):699-713

Fritzsch C*, Baumgärtner S*, Kuban M, Steinshorn D, Reid G# and Legewie S#. (2018).  Estrogen‐dependent control and cell‐to‐cell variability of transcriptional bursting. Mol Syst Biol, 14: e7678

Ghosh B*, Sarma U*, Sourjik V# and Legewie S#. (2018).  Sharing of phosphatases promotes response plasticity in phosphorylation cascades. Biophys J, 114: 223–236

Strasen J*, Sarma U*, Jentsch M*, Bohn S, Sheng C, Horbelt D, Knaus P, Legewie S# and Loewer A#. (2018).  Cell‐specific responses to the cytokine tgfβ are determined by variability in protein levels. Mol Syst Biol, 14: e7733.

Research website