Gene regulation by chromatin remodeling during development and disease

Genomic DNA is highly compacted into chromatin in order to fit into the nucleus of a cell. This packaging provides a regulatory layer for DNA accessibility and therefore all DNA-dependent processes, such as transcription, DNA repair or replication. ATP-dependent chromatin remodelers can modulate chromatin accessibility by moving or evicting nucleosomes. My research focuses on one particular class of chromatin remodelers known as BAF complexes, which are very large multi-protein complexes containing many subunits. Mutations in genes encoding BAF complex proteins occur in more than 20% of all human cancers and developmental diseases. In my research, I use a combination of genomics, proteomics, molecular biology, screening and imaging approaches to dissect the functions of individual BAF subunits in cancer and developmental disease.

Positions held

From May 2020: Research Scientist, IMB, Mainz
2016-2020: Postdoctoral Researcher, CeMM, Vienna

Education

2016: Dr. rer. nat. in Molecular biology, IMB, Mainz
2012: Diplom in Biology, Johannes Gutenberg University, Mainz
2012: Master in Biomedicine, Johannes Gutenberg University, Mainz
2008: Bachelor in Molecular Biology, Johannes Gutenberg University, Mainz

 

Selected publications by Sandra Schick

Schick S, Rendeiro AF, Runggatscher K, Ringler A, Boidol B, Hinkel M, Májek P, Vulliard L, Penz T, Parapatics K, Schmidl C, Menche J, Boehmelt G, Petronczki M, Müller AC, Bock C, Kubicek S (2019) Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Nat Genet 51(9):1399-1410 Link

Sdelci S., Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G, Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P, Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL, Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, Mechtler K, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J, Kubicek S (2019) MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulationNat Genet 51(6):990-998 Link

Thakurela S#, Tiwari N#, Schick S, Garding A, Ivanek R, Berninger B, Tiwari VK (2016) Mapping Gene Regulatory Circuitry of Pax6 During NeurogenesisCell Discov 2:15045 Link

Schick S#, Fournier D#, Thakurela S, Sahu SK, Garding A, Tiwari VK (2015) Dynamics of chromatin accessibility and epigenetic state in response to UV damageJ Cell Sci 128(23):4380-94 Link

Schick S#, Becker K#, Thakurela S, Fournier D, Hampel MH, Legewie S, Tiwari VK (2015) Identifying Novel Circadian Expressed Transcriptional Regulators. Mol Cell Biol 36(4):545-58 Link