Telomere biology and chromosomal inheritance

Telomere shortening is part of normal cell proliferation. In stem cells and many cancers, telomeric DNA is replenished by the enzyme telomerase. Our group was the first to isolate the telomerase RNA subunit (TER1) from fission yeast. We are currently working on defining the roles of RNA chaperones in telomerase biogenesis and uncovering links between RNA processing and quality control in the regulation of telomerase. This will enable us to identify therapeutic compounds that could limit the lifespan of tumour cells or boost the proliferative potential of desired cell populations.

We also study the molecular basis of unisexual reproduction in whiptail lizards, which reproduce without males. By elucidating the molecular basis of unisexual reproduction and understanding the barriers that limit parthenogenesis in most vertebrates, we can better understand how gene regulation changes in evolution.

Research website

Positions held

Since April 2018: Adjunct Director, Institute of Molecular Biology (IMB) and Professor of Molecular Biology, Johannes Gutenberg University, (JGU), Mainz
Since 2013: Professor, University of Kansas Medical Center, Kansas City, USA
2013 – 2018: Howard Hughes Investigator, Kansas City, USA
2013 – 2018: Investigator, Stowers Institute for Medical Research, Kansas City, USA
2009 – 2013: Early Career Scientist, Howard Hughes Medical Institute, Kansas City, USA
2009 – 2013: Associate Professor, University of Kansas Medical Center, Kansas City, USA
2009 – 2012: Associate Investigator, Stowers Institute for Medical Research, Kansas City, USA
2004 – 2008: Assistant Professor, University of Kansas Medical Center, Kansas City, USA
2002 – 2008: Assistant Investigator, Stowers Institute for Medical Research, Kansas City, USA
2000 – 2002: Research Associate, Howard Hughes Medical Institute, University of Colorado, Boulder, USA
1998 – 2000: Postdoc fellow, University of Colorado, Boulder, USA

Education

1998: PhD in Biochemistry, University College London, UK
1994: MPhil in Biochemistry, University of Cambridge, United Kingdom
1993: BA in Cellular and Molecular Biology, University of Cambridge

 

Selected publications by Peter Baumann

Páez-Moscoso DJ, Pan L, Sigauke RF, Schroeder MR, Tang W and Baumann P (2018) Pof8 is a La-related protein and a constitutive component of telomerase in fission yeastNat Commun, 9:587 Link

Tseng CK, Wang H-F, Schroeder MR and Baumann P (2018) The H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARNNat Commun, 9:5430 Link

Cole CJ, Taylor HL, Neaves WB, Baumann DP, Newton A, Schnittker R and Baumann P (2017) The second known tetraploid species of parthenogenetic tetrapod (Reptilia: Squamata: Teiidae): Description, reproduction, comparisons with ancestral taxa, and origins of multiple clonesBull Museum Comp Zool, 161:285–321 Link

Newton AA, Schnittker RR, Yu Z, Munday SS, Baumann DP, Neaves WB and Baumann P (2016) Widespread failure to complete meiosis does not impair fecundity in parthenogenetic whiptail lizardsDevelopment, 143:4486–4494 Link

Kannan R, Helston RM, Dannebaum RO and Baumann P (2015) Diverse mechanisms for spliceosome-mediated 3’ end processing of telomerase RNANat Commun, 6:6104 Link