Molecular mechanisms of hepatocarcinogenesis: from cellular origin to novel therapeutic targets

Jens Marquardt

Positions

  • Since 2015: Lichtenberg Professor for “Molecular Hepatocarcinogenesis”
  • Since 2015: Co-leader Core Facility Bioinformatics (BIUM), University of Mainz, Mainz, Germany
  • Since 2011: Group leader and physician, Department of Internal Medicine I, University of Mainz, Mainz, Germany
  • 2008-2010: Postdoctoral Fellow, Laboratory of Experimental Carcinogenesis (CCR/NCI), Bethesda, MD, USA
  • 2006-2008: Research fellow and physician, Department of Gastroenterology and Hepatology, University Hospital Cologne, Cologne, Germany

Education

  • 2015: Board Certification – Internal Medicine and Gastroenterology
     Medical Chamber Rhineland-Palatinate, Mainz, Germany
  • 2007: Doctor of Medicine (MD), Ruprechts-Karls-University, Medical Faculty, Heidelberg, Germany
  • 2006: License to practice medicine, Ruprechts-Karls-University, Medical Faculty, Heidelberg, Germany

Most relevant publications by Jens Marquardt

Gomez-Quiroz LE, Seo D, Lee YH, Kitade M, Gaiser T, Matthew Gillen M, Gutierrez-Ruiz MC, Palestino-Domínguez M, Lee SB, Conner EA, Factor VM, Thorgeirsson SS and Marquardt JU (2016). Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress.  Toxicology, pii: S0300-483X(16)30121-4

Matter MS, Marquardt JU, Andersen JB, Korokhov N, Stauffer JK, Kaji K, Decaens T, Quintavalle C, Quagliata L, Elloumi F, Hoang F, Hansen K, Molinolo A, Conner EA, Factor VM and Thorgeirsson SS (2016). Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype. Hepatology, 63, 1888-1899

Marquardt JU, Andersen JB and Thorgeirsson SS (2015). Functional and Genetic Deconstruction of the Cellular Origin in Liver Cancer. Nat Rev Cancer, 15, 653-667

Marquardt JU, Gomez-Quiroz L, Arreguin Camacho LO, Pinna F, Lee YH, Kitade M, Palestino Domínguez M, Breuhahn K, Conner EA, Galle PR, Andersen JB, Factor VM and Thorgeirsson SS (2015). Curcumin Effectively Depletes Hepatic Cancer Stem-Like Cells by NF-kB Mediated Inhibition of Histone Deacetylases. J Hepatol, 63, 661-669

Marquardt JU, Seo D, Andersen JB, Gillen MC, Kim MS, Conner EA, Factor VM, Park YN and Thorgeirsson SS (2014). Sequential analysis of hepatocarcinogenesis indicates late stage acquisition of malignant traits. J Hepatol,  60, 346-353

Marquardt JU, Fischer K, Baus K, Krupp M, Linke M, Teufel A., Zechner U, Strand D, Thorgeirsson SS, Galle PR and Strand S (2013). SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients. Hepatology, 58, 1054-1064

Holczbauer A, Factor VM, Andersen JB, Marquardt JU, Kleiner D, Raggi C, Kitade M, Seo D, Hirofumi A, Durkin M and Thorgeirsson SS (2013). Modeling Pathogenesis of Primary Liver Cancer in Lineage Specific Cell Types. Gastroenterology, 145, 221-231

Marquardt JU and Thorgeirsson SS (2014). SnapShot: Hepatocellular Carcinoma. Cancer Cell, 25, 550

Marquardt JU, Raggi C, Andersen JB,  Seo D, Avital I, Geller D, Lee YH, Kitade M, Holczbauer A, Conner EA, Factor VM and Thorgeirsson SS (2011). Human Hepatic Cancer Stem Cells are Characterized by Common Stemness Traits and Diverse Oncogenic Pathways. Hepatology, 54, 1031-1042

Andersen JB, Factor VM, Marquardt JU, Raggi C, Lee YH, Seo D, Conner EA and Thorgeirsson SS (2010). An integrated genomic and pharmacoepigenomic approach predicts therapeutic response of zebularine in human liver cancer. Sci Transl Med, 2, 54ra77

 

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