Circadian clocks as gene regulatory systems

Positions held

  • Since 2013: Professor in Structural Biology, University of Mainz
  • 2012-2013: Group Leader in Structural Biology at Adolf-Butenandt-Institute, LMU Munich
  • 2009-2013: Private Lecturer for Biochemistry LMU, Munich
  • 2009-2011: Cellular Structural Biology at Max-Planck-Institute for Biochemistry, Martinsried
  • 2007-2009: Private Lecturer for Biochemistry at the Ruhr-University, Bochum
  • 2000-2009: Group Leader Max-Planck-Institute for Molecular Physiology, Dortmund
  • 1996-2000: Postdoc, Rockefeller University, New York, USA

Education

  • 2007: Habilitation and venia legend in Biochemistry at Ruhr-University Bochum
  • 1996: PhD in Biology at University Heidelberg
  • 1991: Diploma in Biology at University Heidelberg

Recent publications by Eva Wolf

Garg A, Orru R, Ye W, Distler U, Chojnacki JE, Köhn M, Tenzer S, Sönnichsen C and Wolf E (2019). Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein. J Biol Chem, 294:16604–16619

Li H*, Kilgallen AB*, Münzel T, Wolf E, Lecour S, Schulz R, Daiber A# and Van Laake LW# (2019). Influence of mental stress and environmental toxins on circadian clocks - implications for redox regulation of the heart and cardioprotection. Br J Pharmacol, doi: 10.1111/bph.14949

Merbitz-Zahradnik T and Wolf E (2015). How is the inner circadian clock controlled by interactive clock proteins? Structural analysis of clock proteins elucidates their physiological role. FEBS Lett, 589, 1516-1529

Schmalen I, Reischl S, Wallach T, Klemz R, Grudziecki A, Prabu JR, Benda C, Kramer A and Wolf E (2014). Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation. Cell, 157, 1203–1215

Czarna A, Berndt A, Singh HR, Grudziecki A, Ladurner A, Timinszky G, Kramer A and Wolf E (2013). Structures of Drosophila Cryptochrome and mouse Cryptochrome1 provide insight into circadian function. Cell, 153, 1394-405

Kucera N, Schmalen I, Hennig S, Öllinger R, Strauss HM, Grudziecki A, Wieczorek C, Kramer A and Wolf E (2012). Unwinding the Differences of the Mammalian PERIOD Clock Proteins from Crystal Structure to Cellular Function. PNAS, 109, 3311-3316

Czarna A, Breitkreuz H, Mahrenholz CC, Arens J, Strauss HM and Wolf E (2011). Quantitative analyses of Cryptochrome - mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock. JBC, 286, 22414-22425

Research website