Epigenetics meets superresolution light microscopy

Christoph Cremer

Positions held

  • Since 2015: Research Associate, Max Planck Institute for Chemistry, Mainz
  • Since 2013: Honorary Professor, Johannes Gutenberg University (JGU), Mainz
  • Since 2011: Group Leader, Instute of Molecular Biology (IMB), Mainz
  • Since 2005: Director, Biophysics of Genome Structure, Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg
  • 2005-2007: Deputy Director, Kirchhoff-Institute of Physics, University of Heidelberg
  • 1999-2009: Senate Member, University of Heidelberg
  • 1983-2011: Professor of Applied Optics & Information Processing, University of Heidelberg
  • 1983-1999: Managing/Deputy Director, Institute of Applied Physics I, University of Heidelberg
  • 1970-1983: Staff Scientist, Institute of Human Genetics, University of Freiburg


  • 1983: Habilitation, University of Freiburg
  • 1976: PhD in Biophysics and Genetics, University of Freiburg
  • 1970: Diploma in Physics, Ludwig Maximilian University, Munich

Most relevant publications by Christoph Cremer

Kirmes I, Szczurek A, Prakash K, Charapits  I, Heiser C, Musheev M, Schock F,  Fornalczyk K, Ma D, Birk U, Cremer C and Reid G (2015). A transient ischemic environment induces reversible compaction of chromatin. Genome Biol, 16, 246 

Prakash K, Fournier D, Redl S, Best G, Borsos M, Tiwari VK, Ketting RF, Tachibana-Konwalski K, Cremer C and Birk U (2015). Super-resolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes. Proc Natl Acad Sci U S A, 112, 14635-14640

Markaki Y, Gunkel M, Schermelleh L, Beichmanis S, Neumann J, Heidemann M, Leonhardt H, Eick D, Cremer C and Cremer T (2010). Functional nuclear organization of transcription and DNA replication: a topographical marriage between chromatin domains and the interchromatin compartment. Cold Spring Harbor Symposia on Quantitative Biology, 75, 475-492

Tykocinski L-O, Sinemus A, Rezavandy E, Weiland Y, Baddeley D, Cremer C, Sonntag S, Willeke K, Derbinski J and  Kyewski B (2010). Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells. Proc Natl Acad Sci U S A, 107, 19426-19431

Baddeley D, Chagin VO, Schermelleh L, Martin S, Pombo A, Carlton PM, Gahl A, Domaing P, Birk U, Leonhardt H and Cremer C, Cardoso MC (2010). Measurement of replication structures at the nanometer scale using super-resolution light microscopy. Nucleic Acids Res, 38, e8 1-11

Baddeley D, Batram C, Weiland Y, Cremer C and Birk UJ (2007). Nano-structure analysis using spatially modulated illumination microscopy. Nature Protocols, 2, 2640-2646

Tanabe H, Müller S, Neusser M, von Hase J, Calcagno E, Cremer M, Solovei I, Cremer C, Cremer T (2002). Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates. Proc Natl Acad Sci U S A, 99, 4424-4429

Cremer T and Cremer C (2001). Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat Rev Genet, 2, 292-301

Hell S, Lindek S, Cremer C and Stelzer EHK (1994). Measurement of the 4pi-confocal point spread function proves 75 nm axial resolution. Appl Phys Lett, 64, 1335-1337

Nüsslein-Volhard C, Lohs-Schardin M, Sander K and Cremer C (1980). A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila. Nature, 283, 474-476


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