Crosstalk between DNA damage checkpoints and nutrient signalling

Brian Luke

Positions held

  • Since 2014: Group Leader, Institute of Molecular Biology (IMB), Mainz
  • 2009-2014: Group Leader, ZMBH, Universität Heidelberg
  • 2005-2009: Postdoc, EPFL Lausanne
  • 2005: Postdoctoral Fellow, Biochemistry, ETH Zürich


  • 2005: PhD ETH, Zurich
  • 1999: Bachelor of Science, Biology, Queen’s University, Canada

Most relevant publications by Brian Luke

Klermund J, Bender K and Luke B (2014). High nutrient levels and TORC1 activity reduce cell viability following prolonged telomere dysfunction and cell cycle arrest. Cell Reports, 9, 324-335

Balk B, Dees M, Bender K and Luke B (2014). The differential processing of telomeres in response to increased telomeric transcription and RNA-DNA hybrid accumulation. RNA Biol, 2, 95-100

Balk B*, Maicher A*, Klermund J, Luke-Glaser S, Dees M, Bender K and Luke B (2013). Telomeric RNA-DNA hybrids affect telomere length dynamics and senescence. Nat Struct Mol Biol, 10, 1199-1205

Poschke H*, Dees M*, Chang M, Kaderali L, Amberkar S, Rothstein R and Luke B (2012). Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast. PLoS Genetics, 9, e1002960

Luke-Glaser S and Luke B (2012).The budding yeast helicase Mph1 impairs growth when telomere integrity is compromised. PLoS One, 7, e42028

Maicher A, Kastner L, Dees M and Luke B (2012). Deregulated telomere transcription causes replication dependent telomere shortening and promotes cellular senescence. Nucleic Acids Res, 14, 6649-59

Iglesias N, Redon S, Pfeiffer V, Dees M, Lingner J* and Luke B* (2011).  Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast. EMBO Rep, 6, 587-593

Ferreira H, Luke B, Schober H, Kalck V, Lingner J and Gasser S (2011).  PIAS-homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast. Nature Cell Biol, 7, 867-874

Luke-Glaser S, Luke B, Grossi S and Constantinou A (2010). FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling. EMBO J, 4, 795-805

Chang M, Luke B, Kraft C, Li Z, Peter M, Lingner M and Rothstein R (2009). Telomerase is essential to alleviate Pif1-induced replication stress at telomeres. Genetics, 3, 779-791

Deplazes A, Möckli N, Luke B, Auerbach D and Peter M (2009). Yeast Uri1 promotes translation initiation and may provide a link to cotranslational
quality control. EMBO J, 10, 1429-1441


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