Crosstalk between DNA damage checkpoints and nutrient signalling

Brian Luke

Positions held

  • Since 2017: Adjunct Director, Institute of Molecular Biology (IMB), Mainz
    Professor, Faculty of Biology, Johannes Gutenberg University (JGU), Mainz
  • 2014-2017: Group Leader, Institute of Molecular Biology (IMB), Mainz
  • 2009-2014: Group Leader, ZMBH, Universität Heidelberg
  • 2005-2009: Postdoc, EPFL Lausanne
  • 2005: Postdoctoral Fellow, Biochemistry, ETH Zürich


  • 2005: PhD ETH, Zurich
  • 1999: Bachelor of Science, Biology, Queen’s University, Canada

Recent publications by Brian Luke

Michelini F, Jalihal AP, Francia S, Meers C, Neeb ZT, Rossiello F, Gioia U, Aguado J, Jones-Weinert C, Luke B, Biamonti G, Nowacki M, Storici F, Carninci P, Walter NG and Fagagna FDA Di. (2018). From "cellular" RNA to "smart" RNA: Multiple roles of RNA in genome stability and beyond. Chem Rev, 118, 4365-4403.

Misino S, Bonetti D, Luke-Glaser S, Luke B (2018). Increased TERRA levels and RNase H sensitivity are conserved hallmarks of post-senescent survivors in budding yeast. Differentiation, 100, 37-45

Graf M, Bonetti D, Lockhart A, Serhal K, Maicher A, Jolivet P, Teixeira MT, Luke B (2017). Telomere length determines TERRA and R-loop regulation through the cell cycle. Cell, 170, 72-85

Buser R, Kellner V, Melnik A, Wilson-Zbinden C, Kastner L, Piwko W, Dees M, Picotti P, Maric M, Labib K, Luke B# and Peter M# (2016). The replisome-coupled E3 ubiquitin ligase Rtt101Mms22 counteracts Mrc1 function to tolerate genotoxic stress. PLoS Genet, 12, e1005843 (#indicates joint correspondence)

Dieckmann A, Babin V, Harari Y, Eils R, König R, Luke B# and Kupiec M# (2016). Role of ESCRT complexes in telomere biology. MBio, 7, e01793-16 (#indicates joint correspondence)

Poos A, Maicher A, Dieckmann A, Oswald M, Eils R, Kupiec M, Luke B and König R (2016). Mixed integer linear programming based machine learning approach identifies regulators of telomerase in yeast. Nucleic Acids Res, 44, e93 

Research website