Development and regulation of IL-17 producing cells during inflammation

Position

  • Since 2011: W3 Univ. Prof. and Director, Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz
  • 2010-2011: Acting Director, Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz
  • 2005-2010: W2 Univ. Prof. in the I. Medical Department, University Medical Center of the Johannes Gutenberg-University, Mainz
  • 2001-2005: Independent Group Leader, Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, Cologne, Germany
  • 2000-2001: Research Associate, Department of Immunology, Institute for Genetics, University of Cologne, Cologne, Germany
  • 1996-2000: Post-Doctoral fellow, Department of Immunology, Institute for Genetics, University of Cologne, (K. Rajewsky), Cologne, Germany
  • 1994-1996: Post-Doctoral fellow, Department of Immunology, The Weizmann Institute of Science, (L. Steinman), Rehovot, Israel

Education

  • 1986-1990: Ph.D. with E. Mozes, Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel
  • 1986-1988: M.Sc. with Y. Aloni and O. Laub, Department of Genetics, The Weizmann Institute of Science, Rehovot, Israel
  • 1983-1986: B.Sc. Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel

Most relevant publications by Ari Waisman

Bruttger J, Karram K, Wörtge S, Regen T, Marini F, Hoppmann N, Klein M, Blank T, Yona S, Wolf Y, Mack M, Pinteaux E, Müller W, Zipp F, Binder H, Bopp T, Prinz M, Jung S and Waisman A (2015). Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System. Immunity, 43, 92-106

Waisman A, Ginhoux F, Greter M and Bruttger J (2015). Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems. Trends Immunol, 36, 625-636

Yogev N, Frommer F, Lukas D, Kautz-Neu K, Karram K, Ielo D, von Stebut E, Probst HC, van den Broek M, Riethmacher D, Birnberg T, Blank T, Reizis B, Korn T, Wiendl H, Jung S, Prinz M, Kurschus FC and Waisman A (2012). Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells. Immunity, 37, 264-275

Waisman A (2012). To be 17 again--anti-interleukin-17 treatment for psoriasis. The New England journal of medicine, 366, 1251-1252

Locatelli G, Wortge S, Buch T, Ingold B, Frommer F, Sobottka B, Kruger M, Karram K, Buhlmann C, Bechmann I, Heppner FL, *Waisman A and *Becher B (2012). Primary oligodendrocyte death does not elicit anti-CNS immunity. Nat Neurosci, 15, 543-550

Haak S, Croxford AL, Kreymborg K, Heppner FL, Pouly S, *Becher B and *Waisman A (2009).  IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest, 119, 61-9

Hovelmeyer N, Wunderlich FT, Massoumi R, Jakobsen CG, Song J, Worns MA, Merkwirth C, Kovalenko A, Aumailley M, Strand D, Bruning JC, Galle PR, Wallach D, Fassler R and Waisman A (2007). Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. J Exp Med, 204, 2615-2627

Waisman A, Kraus M, Seagal J, Ghosh S, Melamed D, Song J, Sasaki Y, Classen S, Lutz C, Brombacher F, Nitschke L and Rajewsky K (2007). IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med, 747-758

Buch T, Heppner FL, Tertilt C, Heinen TJ, Kremer M, Wunderlich FT, Jung S and Waisman A (2005). A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nature Methods, 2,  419-26

Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, Mor F, Cohen IR and Steinman L (1996). Suppressive vaccination with DNA encoding a variable region gene of the T cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nature Med, 2, 899-905

*indicates joint corresponding author

 

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