Repair of structurally defined DNA lesions

Andriy Khobta

Positions held

  • Since 2016: Group Leader (Heisenberg Fellowship), Genetic Toxicology, University Medical Center Mainz
  • 2005-2016: Research Scientist, Genetic Toxicology, University of Mainz (habilitation in 2013)
  • 2001-2005: Researcher, Molecular Biology, University of Bologna
  • 2000-2001: IARC Research Fellow, Cancer Biology, University of Bologna
  • 1999-2000: Junior Research Associate, R.E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, Kyiv

Education

  • 1999: PhD in Biology (Oncology), R.E.Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, Kyiv
  • 1995: Diploma (honours) in Biology / Immunology, National Taras Shevchenko University of Kyiv

Most relevant publications by Andriy Khobta

Allgayer J, Kitsera N, Bartelt S, Epe B and Khobta A (2016). Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine. Nucleic Acids Res, 44, 7267-7280

Lühnsdorf B, Epe B and Khobta A (2014). Excision of uracil from transcribed DNA negatively affects the gene expression. J Biol Chem, 289, 22008-22018

Kitsera N, Gasteiger K, Lühnsdorf B, Allgayer J, Epe B, Carell T and Khobta A (2014). Cockayne syndrome: varied requirement of transcription-coupled nucleotide excision repair for the removal of three structurally different adducts from transcribed DNA. PLoS One, 9, e94405

Allgayer J, Kitsera N, von der Lippen C, Epe B and Khobta A (2013). Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence. Nucleic Acids Res, 41, 8559-8571

Kitsera N, Stathis D, Lühnsdorf B, Müller H, Carell T, Epe B and Khobta A (2011). 8-oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription but is converted into transcription-blocking damage by OGG1. Nucleic Acids Res, 39, 5926-5934

Khobta A, Anderhub S, Kitsera N and Epe B (2010). Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region. Nucleic Acids Res, 38, 4285-4295

 

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