At IMB, we explore the molecular biology of the nucleus with an overarching focus on gene regulation, epigenetics & genome stability

Role of Sirt6 during cellular differentiation and cancer

Susanne Strand

Research website

Positions held

  • Since 2012: Professor of Molecular Hepatology (W2), University Medical Center (UMC), Mainz
  • 1998 - 2012: Group Leader at the I. Department of Internal Medicine, University Medical Center (UMC), Mainz
  • 1995 - 1998: Postdoc, Dept. of Gastroenterology, University Hospital Heidelberg and I. Department of Internal Medicine, University Medical Center (UMC), Mainz

Education

  • 2005: Habilitation and venia legendi in Molecular Medicine, Faculty of Medicine, Johannes Gutenberg University (JGU), Mainz
  • 1995 - 1998: Postdoctoral research with Prof. P. Galle, University Hospital, Dept. of Gastroenterology, Heidelberg
  • 1990 - 1994: PhD with Prof. F. Marks, German Cancer Research Center (DKFZ), Heidelberg
  • 1990: Diploma in Biology, University of Heidelberg

Selected publications by Susanne Strand

Steinmetz C, Kashyap A, Zhivkova N, Alizor H, Ernst I, Gottfried-Brand D, Janssen H, Teufel A, Schulze-Bergkamen H, Lotz J, Kuball J, Theobald M, Heise M, Lang H, Galle PR, Strand D, Strand S (2017) Activation of silent mating type information regulation 2 homolog 1 by human chorionic gonadotropin exerts a therapeutic effect on hepatic injury and inflammation. Hepatology, 65(6):2074-2089 Link

Wolf K, Strand S (2017) Assessing the Histone Deacetylase Activity of SIRT6 in Primary Murine Hepatocytes via Proximity Ligation Assay. Methods Mol Biol, 1510:149-158 Link

Etzold A, Galetzka D, Weis E, Bartsch O, Haaf T, Spix C, Itzel T, Schweiger S, Strand D, Strand S* and Zechner U* (2016) CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumour suppressor deficiency-related changes in healthy tissue. Epigenetics, 11:120-131 (*indicates equal senior authorship) Link

Marquard JU, Fischer K, Baus K, Kashyap A, Ma S, Krupp M, Linke M, Teufel A, Zechner U, Strand D, Thorgeirsson SS, Galle PR and Strand S (2013) Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. Hepatology, 58:1054-1064 Link