Role of Sirt6 during cellular differentiation and cancer

Positions held

  • Since 2012: Professor of Molecular Hepatology (W2)
    at the University Medical Center Mainz
  • 1998-2012: Group Leader at the I. Department of Internal Medicine,
    University Medical Center Mainz
  • 1995-1998: Postdoc, Dept. of Gastroenterology, University Hospital Heidelberg
    and I. Department of Internal Medicine, University Medical Center Mainz


  • 2005: Habilitation and venia legendi in Molecular Medicine,
    Faculty of Medicine, University of Mainz
  • 1995-1998: Postdoctoral research with Prof. P. Galle,
    University Hospital, Dept. of Gastroenterology, Heidelberg
  • 1990-1994: PhD with Prof. F. Marks,
    German Cancer Research Center (DKFZ), Heidelberg
  • 1990: Diploma in Biology,
    University of Heidelberg

Most relevant publications by Susanne Strand

Etzold A, Galetzka D, Weis E, Bartsch O, Haaf T, Spix C, Itzel T, Schweiger S, Strand D, Strand S* and Zechner U* (2016). CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumour suppressor deficiency-related changes in healthy tissue. Epigenetics, 11, 120-131, doi: 10.1080/15592294.2016.1140295 *equal senior authorship

Marquard JU, Fischer K, Baus K, Kashyap A, Ma S, Krupp M, Linke M, Teufel A, Zechner U, Strand D, Thorgeirsson SS, Galle PR and Strand S (2013). SIRT-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients. Hepatology, 58, 1054-1064, doi: 10.1002/hep.26413

Carbajo-Pescador S, Steinmetz C, Kashyap A, Lorenz S, Mauriz JL, Heise M, Galle PR, González-Gallego J and Strand S (2013). Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells. Br J Cancer, 108, 442-449

Kashyap A, Zimmermann T, Ergül N, Bosserhoff A, Hartman U, Alla V, Bataille F, Galle PR, Strand S* and Strand D* (2012). The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorgenesis. Oncogene, doi: 10.1038/onc.2012.162. *equal senior authorship

Barreiros AP, Sprinzl M, Rosset S, Höhler T, Otto G, Theobald M, Galle PR, Strand D and Strand S (2009). EGF and HGF levels are increased during active HBV infection and enhance survival signaling through extracellular matrix interactions in primary human hepatocytes. Int J Cancer, 124, 120-129

Su Z, Kuball J, Barreiros A-P, Gottfried D, Antunes Ferreira A, Theobald M, Galle PR, Strand D and Strand S (2006). Nitric oxide promotes resistance to tumor suppression by CTLs. J Immunol, 176, 3923-3930

Strand S, Strand D, Seufert R, Mann A, Lotz J, Blessing M, Lahn M, Wunsch A, Broering DC, Hahn U, Grischke EM, Rogiers X, Otto G, Gores GJ and Galle PR (2004). Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome. Gastroenterology, 126, 849-858

Strand S, Hofmann WJ, Grambihler A, Hug H, Volkmann M, Otto G, Wesch H, Mariani SM, Stremmel W, Krammer PH and Galle PR (1998). Hepatic failure and liver cell damage in acute Wilson´s disease involve CD95 (APO-1/Fas) mediated apoptosis. Nature Med, 4, 588-593

Strand S, Hofmann WJ, Hug H, Müller M, Otto G, Mariani SM, Stremmel W, Krammer PH and Galle PR (1996). Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand expressing tumor cells - A mechanism of immune evasion? Nature Med, 2, 1361-1367


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