Deciphering the molecular basis of rapid antidepressant action


  • Since 2016: Member, Steering Committee, SFB 1193 "Neurobiology of Resilience"
  • Since 2014: Principal Investigator, Deutsches Resilienz-Zentrum Mainz
  • Since 2014: Professorship (W2) in Translational Psychiatry, University of Mainz (primo loco)
  • 2004-2013: Head, Independent Research Group Molecular Stress Physiology (Max Planck Institute of Psychiatry, Munich)
  • 2004-2013: Minerva Program (Professorship Award/W2 for outstanding female scientists) from the Max Planck Society for the Advancement of Science
  • 2004–2007: Assistant Medical Director, Open Psychiatric Ward (Oberärztin)
  • 2003: Board certification, Psychiatry (Fachärztin f. Psychiatrie u. Psychotherapie)
  • 1997: Visiting scientist at the Netherlands Institute for Brain Research, Amsterdam, The Netherlands (Supervisor: Prof. Dr. D.F. Swaab)
  • 1996–2003: Residency in Psychiatry and Neurology, clinical training (Max Planck Institute of Psychiatry, Munich)
  • 1996–2003: Postdoctoral Researcher, Molecular Neurogenetics, Max Planck Institute of Psychiatry, Munich (Prof. Dr. W. Wurst)
  • 1996: Postdoctoral Fellow, Dep. of Neuropathology, University of Bonn Medical Center (Supervisor: Prof. Dr. O.D.Wiestler)


  • 2004: Privatdozentin (Habilitation); Venia Legendi in Psychiatry and Psychotherapy, Ludwig Maximilian University Munich
  • 1996: M.D. degree award, Institute of Neuropathology, University of Bonn (Prof. Dr. O.D. Wiestler)

Relevant publications by Marianne Müller

van der Kooij MA, Masana M, Rust MB and Müller MB (2016). The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior. Neurosci Biobehav Rev, 62, 69-75

Kalisch R, Müller MB and Tüscher O (2015). A conceptual framework for the neurobiological study of resilience. Behav Brain Sci. 38, e92

Filser S, Jung CK, ..., Masana M, Müller MB, Ovsepian SV and Herms J (2015). Pharmacological inhibition of BACE1 impairs dendritic spine formation and synaptic plasticity. Biol Psychiatry, 77, 729-739

Masana M, Su Y-A, Jansen L, Westerholz S, Liebl C, Wagner KV, Schmidt MV, Rein T and Müller MB (2014). The stress-inducible actin-interacting protein DRR1 shapes social behavior. Psychoneuroendocrinology, 48, 98-110

Wang XD, Su Y, Wagner KV, ..., Deussing JM, Müller MB and Schmidt MV (2013). Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nat Neurosci, 6, 706-713

Schmidt MV, Schülke JP, Liebl C, ..., Wurst W, Holsboer F, Stewart MG, Bradke F, Eder M, Müller MB* and Rein T* (2011). The tumor suppressor DRR1 is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition. Proc Natl Acad Sci USA, 108, 17213-17218 *equal contribution.

Kohli, MA, Lucae S, Sämann PG, Schmidt MV, ... Schreiber S, Czisch M, Müller MB, Uhr M, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B and Binder EB (2011). The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron, 70, 252-265

Schmidt MV, Trümbach D, Weber P, Wagner K, Scharf SH, Liebl C, Datson N, Namendorf C, Gerlach T, Kühne C, Uhr M, Deussing JM, Wurst W, Binder EB, Holsboer F and Müller MB (2010). Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus. Journal of Neuroscience, 30, 16949-16958

Schmidt MV, Sterlemann V, Ganea K, Alam S, Harbich D, Greetfeld M, Uhr M, Holsboer F and Müller MB (2007). Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence. Psychoneuroendocrinology, 32, 417-429

Müller MB and Holsboer F (2006). Mice with mutations in the HPA-System as models for symptoms of depression. Biological Psychiatry, 59, 1104-1115

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