The DNA damage response in colorectal carcinogenesis

Jörg Fahrer

Position

  • Since 2012: Group leader, Institute of Toxicology, University Medical Center Mainz
  • 2008-2011: Postdoctoral fellow, Institute of Pharmacology & Toxicology, University of Ulm Medical Center
  • 2004-2007: Research associate, Molecular Toxicology Group, University of Konstanz

Education

  • 2016: Habilitation and venia legendi, Medical Faculty (Toxicology), University of Mainz
  • 2004-2007: PhD (summa cum laude) with Prof. Dr. Alexander Bürkle, University of Konstanz
  • 2004: Diploma in Food Chemistry (highest distinction), University of Karlsruhe

Most relevant publications by Jörg Fahrer

Mimmler M, Peter S, Kraus A, Stroh S, Nikolova T, Seiwert N, Hasselwander S, Neitzel C, Haub J, Monien B, Nicken P, Steinberg P, Shay JW, Kaina B and Fahrer J* (2016). DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP. Nucleic Acids Res, pii: gkw791 Epub ahead of print

Mikhed Y‡, Fahrer J‡, Oelze M‡, Kröller-Schön S, Steven S, Welschof P, Zinßius E, Stamm P, Kashani F, Roohani S, Kreß J, Ullman E., Tran LP, Schulz E, Epe B, Kaina B, Münzel T and Daiber A (2016). Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate tolerance. Basic Res Cardiol, 111, 52

Fahrer J*, Frisch J, Nagel G, Kraus A, Dörsam B, Thomas AD, Reißig S, Waisman A and Kaina B (2015). DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. Carcinogenesis, 36, 1235-1244

Dörsam B, Göder A, Seiwert N, Kaina B and Fahrer J* (2015). Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates 5-fluorouracil-dependent cytotoxicity, Arch Toxicol, 89, 1829-1846     

Göder A, Nagel G, Kraus A, Dörsam B, Seiwert N, Kaina B and Fahrer J* (2015). Lipoic acid inhibits the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. Carcinogenesis, 36, 817-831

Fahrer J, Huelsenbeck J‡, Jaurich H, Dörsam B, Frisan T, Eich M, Roos WP, Kaina B and Fritz G (2014). Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent DNA double-strand breaks in human fibroblasts. DNA repair, 18, 31-43

Lillich M, Chen X, Weil T, Barth H* and Fahrer J* (2012). Streptavidin-conjugated C3 protein mediates the delivery of mono-biotinylated RNAse A into macrophages. Bioconjug Chem, 23, 1426-1436

Fahrer J, Plunien R, Binder U, Langer T, Seliger H and Barth H (2010). Genetically engineered clostridial C2 toxin as a novel delivery system for living mammalian cells. Bioconjug Chem, 21, 130-139

Kappes F, Fahrer J, Khodadoust, MS, Tabbert A, Strasser C, Mor-Vaknin N, Moreno-Villanueva M, Bürkle A, Markovitz, DM and Ferrando-May E (2008). DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. Mol Cell Biol, 28, 3245-3257

Fahrer J, Kranaster R, Altmeyer M, Marx A and Bürkle, A (2007). Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length. Nucleic Acids Res, 35, e143

* corresponding author,  ‡ shared first-authorship

 

Research website