Molecular mechanisms of hepatocarcinogenesis: from cellular origin to novel therapeutic targets


  • Since 2015: Lichtenberg Professor for “Molecular Hepatocarcinogenesis”
  • Since 2015: Co-leader Core Facility Bioinformatics (BIUM), University of Mainz, Mainz, Germany
  • Since 2011: Group leader and physician, Department of Internal Medicine I, University of Mainz, Mainz, Germany
  • 2008-2010: Postdoctoral Fellow, Laboratory of Experimental Carcinogenesis (CCR/NCI), Bethesda, MD, USA
  • 2006-2008: Research fellow and physician, Department of Gastroenterology and Hepatology, University Hospital Cologne, Cologne, Germany


  • 2015: Board Certification – Internal Medicine and Gastroenterology
     Medical Chamber Rhineland-Palatinate, Mainz, Germany
  • 2007: Doctor of Medicine (MD), Ruprechts-Karls-University, Medical Faculty, Heidelberg, Germany
  • 2006: License to practice medicine, Ruprechts-Karls-University, Medical Faculty, Heidelberg, Germany

Recent publications by Jens Marquardt

Heinrich B, Czauderna C, Marquardt JU (2018). Immunotherapy of Hepatocellular Carcinoma. Oncol Res Treat, 41(5):292-297

Foerster F, Hess M, Gerhold-Ay A, Marquardt JU, Becker D, Galle PR, Schuppan D, Binder H, Bockamp E (2018).The immune contexture of hepatocellular carcinoma predicts clinical outcome. Sci Rep, 8(1):5351

Nault JC, Galle PR, Marquardt JU (2018). The role of molecular enrichment on future therapies in hepatocellular carcinoma. J Hepatol, 69(1):237-247

Labenz C, Prenosil V, Koch S, Huber Y, Marquardt JU, Schattenberg JM, Galle PR, Weinmann A, Wörns MA (2017). Impact of Individual Components of the Metabolic Syndrome on the Outcome of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib. Dig Dis, doi: 10.1159/000477578. [Epub ahead of print]

Castven D, Fischer M, Becker D, Heinrich S, Andersen JB, Strand D, Sprinzl MF, Strand S, Czauderna C, Heilmann-Heimbach S, Roessler S, Weinmann A, Wörns MA, Thorgeirsson SS, Galle PR, Matter MS, Lang H, Marquardt JU (2017). Adverse genomic alterations and stemness features are induced by field cancerization in the microenvironment of hepatocellular carcinomas.Oncotarget, 25;8, 48688-48700

Marquardt JU, Nguyen-Tat M, Galle PR, Wörns MA (2016). Surveillance of Hepatocellular Carcinoma and Diagnostic Algorithms in Patients with Liver Cirrhosis.Visc Med, 32, 110-5

Research website