DNA Demethylation, DNA Repair and Reprogramming

Christof Niehrs

Positions held

  • Since 2010: Founding & Scientific Director, Institute of Molecular Biology (IMB), Mainz; Professor at the Faculty of Biology, University of Mainz
  • 2010-2015: Executive Director, IMB, Mainz
  • Since 2000: Professor of Molecular Embryology, DKFZ, Heidelberg
  • Since 1994: Head of Division "Molecular Embryology", German Cancer Research Center (DKFZ), Heidelberg
  • 1990-1993: Postdoc, University of California Los Angeles


  • 1997: Habilitation, Faculty of Biology (Zoology), University of Heidelberg
  • 1990: PhD, EMBL, Heidelberg
  • 1985: Diploma in Biochemistry, Free University of Berlin

Publications relevant to the projects:

Schäfer A, Karaulanov E, Stapf U, Döderlein G and Niehrs C (2013). Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3. Genes Dev, 27, 261-273

Gierl MS, Gruhn WH, von Seggern A, Maltry N and Niehrs C (2012). GADD45G Functions in Male Sex Determination by Promoting p38 Signaling and Sry Expression. Dev Cell, 23, 1032-1042

Niehrs C and Schäfer A (2012). Active DNA demethylation by Gadd45 and DNA repair. Trends Cell Biol, 22, 220-227

Kaufmann LT and Niehrs C (2011). Gadd45a and Gadd45g regulate neural development and exit from pluripotency in Xenopus. Mech Dev, 128, 401-411

Barreto G, Schäfer A, Marhold J, Stach D, Döderlein G, Maltry N, Swaminathan SK, Lyko F and Niehrs C (2007). Gadd45 promotes epigenetic gene activation by repair mediated DNA demethylation. Nature, 445, 671-675


  Research website