Responses to structurally defined DNA lesions

Andriy Khobta

Positions held

  • Since 2016: Group Leader (Heisenberg Fellowship), Genetic Toxicology, University Medical Center Mainz
  • 2005-2016: Research Scientist, Genetic Toxicology, University of Mainz (habilitation in 2013)
  • 2001-2005: Researcher, Molecular Biology, University of Bologna
  • 2000-2001: IARC Research Fellow, Cancer Biology, University of Bologna
  • 1999-2000: Junior Research Associate, R.E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, Kyiv

Education

  • 1999: PhD in Biology (Oncology), R.E.Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, Kyiv
  • 1995: Diploma (honours) in Biology / Immunology, National Taras Shevchenko University of Kyiv

Recent publications by Andriy Khobta

Kitsera, N, Allgayer, J, Parsa, E, Geier, N, Rossa, M, Carell, T, Khobta A (2017). A Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter. Nucleic Acids Res (in press) doi: 10.1093/nar/gkx718

Allgayer J, Kitsera N, Bartelt S, Epe B and Khobta A (2016). Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine. Nucleic Acids Res, 44, 7267-7280

Lühnsdorf B, Epe B and Khobta A (2014). Excision of uracil from transcribed DNA negatively affects the gene expression. J Biol Chem, 289, 22008-22018

Kitsera N, Gasteiger K, Lühnsdorf B, Allgayer J, Epe B, Carell T and Khobta A (2014). Cockayne syndrome: varied requirement of transcription-coupled nucleotide excision repair for the removal of three structurally different adducts from transcribed DNA. PLoS One, 9, e94405

Allgayer J, Kitsera N, von der Lippen C, Epe B and Khobta A (2013). Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence. Nucleic Acids Res, 41, 8559-8571

Research website