Schick S*, Becker K*, Thakurala S, Fournier D, Hampel MH, Legewie S# and Tiwari VK# (2016). Identifying novel circadian transcriptional regulators. Mol Cell Biol, 36, 545-558 (*indicates joint contribution,#indicates joint correspondence)

Kamenz, J, Mihaljev T, Kubis A, Legewie S#, Hauf S# (2015). Robust ordering of anaphase events by adaptive thresholds and competing degradation pathways. Mol Cell, 60, 446-459 (#indicates joint correspondence)

Bastiaens P, Birtwistle M, Blüthgen N, Bruggeman F, Cho K, Cosentino C, de la Fuente A, Hoek J, Kiyatkin A, Klamt S, Kolch W, Legewie S, Mendes P, Naka T, Santra T, Sontag E, Westerhoff H, Kholodenko B (2015). Silence on the relevant literature and errors in implementation. Nat Biotech, 33, 4, 5-7

Casanovas G, Banerji A, d'Alessio F, Muckenthaler M#, Legewie S# (2014). A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis. PLoS Comput Biol, doi: 10.1371/journal.pcbi.1003421 (#indicates joint correspondence)

Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S# and Eils R# (2014). Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis. Science Signaling, 7, ra23 (Editors' Choice in Science 343, 1178) (#indicates joint correspondence)

Blüthgen N and Legewie S (2013). Robustness of signal transduction pathways. Cell Mol Life Sci, 70, 2259-69

Jeschke M, Baumgärtner S, and Legewie S (2013). Determinants of cell-to-cell variability in protein kinase signaling. PLoS Comput Biol, 9, e1003357

Kallenberger S, Legewie S and Eils R (2013). Applications in cancer research: Mathematical models of apoptosis. In Computational Systems Biology, 2nd edition (Kriete A, Eils R, Eds.), Elsevier

Kallenberger S and Legewie S (2012). Modeling formalisms in systems biology of apoptosis. In: Systems Biology of Apoptosis, (Ed. Lavrik I), Springer Press, 1-32

Schmidt-Glenewinkel HS, Reinz E, Bulashevska S, Beaudouin J, Legewie S, Alonso A and Eils R (2012). Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR. Febs Lett, 586, 1179-1189

Schmiedel J, Axmann I and Legewie S (2012). Multi-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior. PLoS One, 7, e42296

Stelniec I*, Legewie S*, Tchernitsa O, Bobbe S, Sers C, Herzel H, Blüthgen N and Schäfer R (2012). Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS. Mol Syst Biol, 8, 601 (*indicates joint contribution)

Kober M*, Legewie S*, Pforr C, Fricker N, Eils R, Krammer PH and Lavrik I (2011). Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation. Cell Death Dis, 2, e212 (*indicates joint contribution)

Legewie S, Koenig R and Schmidt-Glenewinkel H (2011). Cellular Systems Biology. In: An Introduction to Molecular Biotechnology, (Ed. Wink M), Wiley-VCH

Paulsen M*, Legewie S*, Eils R, Karaulanov E and Niehrs C (2011). Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci U S A, 108, 10202-10207 (*indicates joint contribution) (Editors' Choice in Science 333, 138)

Nazarenko I, Jenny M, Keil J, Gieseler C, Weisshaupt K, Sehouli J, Legewie S, Herbst L, Weichert W, Darb-Esfahani S, Dietel M, Schafer R, Ueberall F and Sers C (2010). Atypical Protein Kinase C zeta exhibits a proapoptotic function in ovarian cancer. Molecular Cancer Research, 8, 919-934

Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schafer R, Herzel H and Sers C (2009). A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts. Febs Journal, 276, 1024-1035

Borisov N, Aksamitiene E, Kiyatkin A, Legewie S, Berkhout J, Maiwald T, Kaimachnikov NP, Timmer J, Hoek JB and Kholodenko BN (2009). Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. Molecular Systems Biology, 5, 256

Legewie S, Sers C and Herzel H (2009). Kinetic mechanisms for overexpression insensitivity and oncogene cooperation. Febs Letters, 583, 93-96

Blüthgen N and Legewie S (2008). Systems analysis of MAPK signal transduction. Essays in Biochemistry: Systems Biology Vol 45, 95-107

Chauhan A*, Legewie S*, Westermark PO, Lorenzen S and Herzel H (2008). Mesoscale model of G1/S phase transition in liver regeneration. Journal of Theoretical Biology, 252, 465-473 (*indicates joint contribution)

Legewie S, Dienst D, Wilde A, Herzel H and Axmann IM (2008). Small RNAs establish delays and temporal thresholds in gene expression. Biophysical Journal, 95, 3232-3238

Legewie S, Herzel H, Westerhoff HV and Bluthgen N (2008). Recurrent design patterns in the feedback regulation of the mammalian signalling network. Molecular Systems Biology, 4, 190

Axmann IM, Legewie S and Herzel H (2007). A minimal circadian clock model. Genome Informatics, 18, 54-64

Blüthgen N LS, Herzel H, Kholodenko B (2007). Mechanisms generating ultrasensitivity, bistability and oscillation in signal transduction. In: Introduction to Systems Biology, (Ed. Choi S), Humana Press

Legewie S, Schoeberl B, Blüthgen N and Herzel H (2007). Competing docking interactions can bring about bistability in the MAPK cascade. Biophysical Journal, 93, 2279-2288

Blüthgen N, Bruggeman FJ, Legewie S, Herzel H, Westerhoff HV and Kholodenko BN (2006). Effects of sequestration on signal transduction cascades. FEBS J, 273, 895-906

Legewie S, Blüthgen N and Herzel H (2006). Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLoS Computational Biology, 2, 1061-1073