Enculescu M, Braun S, Setty ST, Zarnack K, König J and Legewie S (2019) Exon definition facilitates reliable control of alternative splicing. Biorxiv, doi: 10.1101/714022 Link


Becker K, Bluhm A*, Casas-Vila N*, Dinges N*, Dejung M, Sayols S, Kreutz C, Roignant J-Y, Butter F# and Legewie S# (2018) Quantifying post-transcriptional regulation in the development of Drosophila melanogaster. Nat Commun, 9:4970 (*indicates joint contribution, #indicates joint correspondence) Link

Braun S*, Enculescu M*, Setty ST*, Cortés-López M, de Almeida BP, Sutandy FXR, Schulz L, Busch A, Seiler M, Ebersberger S, Barbosa-Morais NL, Legewie S#, König J# and Zarnack K# (2018) Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis. Nat Commun, 9:3315 (*indicates joint contribution, #indicates joint correspondence) Link

Fritzsch C*, Baumgärtner S*, Kuban M, Steinshorn D, Reid G# and Legewie S# (2018) Estrogen‐dependent control and cell‐to‐cell variability of transcriptional bursting. Mol Syst Biol, 14:e7678 (*indicates joint contribution, #indicates joint correspondence) Link

Ghosh B*, Sarma U*, Sourjik V# and Legewie S# (2018) Sharing of phosphatases promotes response plasticity in phosphorylation cascades. Biophys J, 114:223–236 (*indicates joint contribution, #indicates joint correspondence) Link

Strasen J*, Sarma U*, Jentsch M*, Bohn S, Sheng C, Horbelt D, Knaus P, Legewie S# and Loewer A# (2018) Cell‐specific responses to the cytokine TGFβ are determined by variability in protein levels. Mol Syst Biol, 14:e7733 (*indicates joint contribution, #indicates joint correspondence) Link

Sutandy FXR*, Ebersberger S*, Huang L*, Busch A, Bach M, Kang H-S, Fallmann J, Maticzka D, Backofen R, Stadler PF, Zarnack K, Sattler M, Legewie S# and König J# (2018) In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors. Genome Res, 28:699–713 (*indicates joint contribution, #indicates joint correspondence) Link


Enculescu M*, Metzendorf C*, Sparla R, Hahnel M, Bode J, Muckenthaler MU# and Legewie S# (2017) Modelling systemic iron regulation during dietary iron overload and acute inflammation: Role of hepcidin-independent mechanisms. PLOS Comput Biol, 13:e1005322 (*indicates joint contribution, #indicates joint correspondence) Link

Kallenberger SM, Unger AL, Legewie S, Lymperopoulos K, Klingmüller U, Eils R and Herten D-P (2017) Correlated receptor transport processes buffer single-cell heterogeneity. PLOS Comput Biol, 13:e1005779 Link


Schick S*, Becker K*, Thakurela S, Fournier D, Hampel MH, Legewie S# and Tiwari VK# (2016) Identifying novel transcriptional regularors with circadian expression. Mol Cell Biol, 36:545–558 (*indicates joint contribution, #indicates joint correspondence) Link


Bastiaens P, Birtwistle MR, Blüthgen N, Bruggeman FJ, Cho K-H, Cosentino C, de la Fuente A, Hoek JB, Kiyatkin A, Klamt S, Kolch W, Legewie S, Mendes P, Naka T, Santra T, Sontag E, Westerhoff H V and Kholodenko BN (2015) Silence on the relevant literature and errors in implementation. Nat Biotechnol, 33:336–339 Link

Kamenz J, Mihaljev T, Kubis A, Legewie S# and Hauf S# (2015) Robust ordering of anaphase events by adaptive thresholds and competing degradation pathways. Mol Cell, 60:446–459 (#indicates joint correspondence) Link


Casanovas G, Banerji A, D’Alessio F, Muckenthaler MU# and Legewie S# (2014) A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis. PLOS Comput Biol, 10:e1003421 (#indicates joint correspondence) Link

Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S# and Eils R# (2014) Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Sci Signal, 7:ra23 (#indicates joint correspondence) Link

Kallenberger SM, Legewie S and Eils R (2014) Applications in cancer research: Mathematical models of apoptosis. Pages 455–481 in: Computational Systems Biology (eds. Eils R & Kriete A), Academic Press, Amsterdam  Link


Blüthgen N and Legewie S (2013) Robustness of signal transduction pathways. Cell Mol Life Sci, 70:2259–2269 Link

Jeschke M, Baumgärtner S and Legewie S (2013) Determinants of cell-to-cell variability in protein kinase signaling. PLOS Comput Biol, 9:e1003357 Link


Kallenberger S and Legewie S (2012) Modeling formalisms in systems biology of apoptosis. Pages 1–32 in: Systems Biology of Apoptosis (ed. Lavrik IN), Springer, New York  Link

Schmidt-Glenewinkel H, Reinz E, Bulashevska S, Beaudouin J, Legewie S, Alonso A and Eils R (2012) Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR. FEBS Lett, 586:1179–1189 Link

Schmiedel JM, Axmann IM and Legewie S (2012) Multi-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior. PLOS One, 7:e42296 Link

Stelniec-Klotz I*, Legewie S*, Tchernitsa O, Witzel F, Klinger B, Sers C, Herzel H, Blüthgen N and Schäfer R (2012) Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS. Mol Syst Biol, 8:601 (*indicates joint contribution) Link


Kober AMM*, Legewie S*, Pforr C, Fricker N, Eils R, Krammer PH and Lavrik IN (2011) Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation. Cell Death Dis, 2:e212 (*indicates joint contribution) Link

Paulsen M*, Legewie S*, Eils R, Karaulanov E and Niehrs C (2011) Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci USA, 108:10202–10207 (*indicates joint contribution) Link

Schmidt-Glenewinkel, Hannah LS, Brors B and König R (2011) Cellular Systems Biology. Pages 295–314 in: An introduction to molecular biotechnology: Fundamentals, methods and applications (ed. Wink M), Wiley-Blackwell, Weinheim Link


Nazarenko I, Jenny M, Keil J, Gieseler C, Weisshaupt K, Sehouli J, Legewie S, Herbst L, Weichert W, Darb-Esfahani S, Dietel M, Schafer R, Ueberall F and Sers C (2010) Atypical protein kinase C ζ exhibits a proapoptotic function in ovarian cancer. Mol Cancer Res, 8:919–934 Link


Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schäfer R, Herzel H and Sers C (2009) A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts. FEBS J, 276:1024–1035 Link

Borisov N, Aksamitiene E, Kiyatkin A, Legewie S, Berkhout J, Maiwald T, Kaimachnikov NP, Timmer J, Hoek JB and Kholodenko BN (2009) Systems-level interactions between insulin–EGF networks amplify mitogenic signaling. Mol Syst Biol, 5:256 Link

Legewie S, Sers C and Herzel H (2009) Kinetic mechanisms for overexpression insensitivity and oncogene cooperation. FEBS Lett, 583:93–96 Link


Blüthgen N and Legewie S (2008) Systems analysis of MAPK signal transduction. Essays Biochem, 45:95–108 Link

Chauhan A*, Legewie S*, Westermark PO, Lorenzen S and Herzel H (2008) A mesoscale model of G1/S phase transition in liver regeneration. J Theor Biol, 252:465–473 (*indicates joint contribution) Link

Legewie S, Dienst D, Wilde A, Herzel H and Axmann IM (2008) Small RNAs establish delays and temporal thresholds in gene expression. Biophys J, 95:3232–3238 Link

Legewie S, Herzel H, Westerhoff H V and Blüthgen N (2008) Recurrent design patterns in the feedback regulation of the mammalian signalling network. Mol Syst Biol, 4:190 Link


Axmann IM, Legewie S and Herzel H (2007) A minimal circadian clock model. Genome Inform, 18:54–64 Link

Blüthgen N, Legewie S, Herzel H and Kholodenko B (2007) Mechanisms generating ultrasensitivity, bistability, and oscillations in signal transduction. Pages 282–299 in: Introduction to systems biology (ed. Choi S), Humana Press, Totowa ISBN 978-1-59745-531-2

Legewie S, Schoeberl B, Blüthgen N and Herzel H (2007) Competing docking interactions can bring about bistability in the MAPK cascade. Biophys J, 93:2279–2288 Link


Bluthgen N, Bruggeman FJ, Legewie S, Herzel H, Westerhoff H V. and Kholodenko BN (2006) Effects of sequestration on signal transduction cascades. FEBS J, 273:895–906 Link

Legewie S, Blüthgen N and Herzel H (2006) Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLOS Comput Biol, 2:e120 Link