Enculescu M#, Braun S, Thonta Setty S, Busch A, Zarnack K, König J# and Legewie S# (2020) Exon Definition Facilitates Reliable Control of Alternative Splicing in the RON Proto-Oncogene. Biophys J, 118:2027–2041 Link


Becker K, Bluhm A*, Casas-Vila N*, Dinges N*, Dejung M, Sayols S, Kreutz C, Roignant J-Y, Butter F# and Legewie S# (2018) Quantifying post-transcriptional regulation in the development of Drosophila melanogaster. Nat Commun, 9:4970 (*indicates joint contribution, #indicates joint correspondence) Link

Braun S*, Enculescu M*, Setty ST*, Cortés-López M, de Almeida BP, Sutandy FXR, Schulz L, Busch A, Seiler M, Ebersberger S, Barbosa-Morais NL, Legewie S#, König J# and Zarnack K# (2018) Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis. Nat Commun, 9:3315 (*indicates joint contribution, #indicates joint correspondence) Link

Fritzsch C*, Baumgärtner S*, Kuban M, Steinshorn D, Reid G# and Legewie S# (2018) Estrogen‐dependent control and cell‐to‐cell variability of transcriptional bursting. Mol Syst Biol, 14:e7678 (*indicates joint contribution, #indicates joint correspondence) Link

Ghosh B*, Sarma U*, Sourjik V# and Legewie S# (2018) Sharing of phosphatases promotes response plasticity in phosphorylation cascades. Biophys J, 114:223–236 (*indicates joint contribution, #indicates joint correspondence) Link

Strasen J*, Sarma U*, Jentsch M*, Bohn S, Sheng C, Horbelt D, Knaus P, Legewie S# and Loewer A# (2018) Cell‐specific responses to the cytokine TGFβ are determined by variability in protein levels. Mol Syst Biol, 14:e7733 (*indicates joint contribution, #indicates joint correspondence) Link

Sutandy FXR*, Ebersberger S*, Huang L*, Busch A, Bach M, Kang H-S, Fallmann J, Maticzka D, Backofen R, Stadler PF, Zarnack K, Sattler M, Legewie S# and König J# (2018) In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors. Genome Res, 28:699–713 (*indicates joint contribution, #indicates joint correspondence) Link


Enculescu M*, Metzendorf C*, Sparla R, Hahnel M, Bode J, Muckenthaler MU# and Legewie S# (2017) Modelling systemic iron regulation during dietary iron overload and acute inflammation: Role of hepcidin-independent mechanisms. PLOS Comput Biol, 13:e1005322 (*indicates joint contribution, #indicates joint correspondence) Link

Kallenberger SM, Unger AL, Legewie S, Lymperopoulos K, Klingmüller U, Eils R and Herten D-P (2017) Correlated receptor transport processes buffer single-cell heterogeneity. PLOS Comput Biol, 13:e1005779 Link


Schick S*, Becker K*, Thakurela S, Fournier D, Hampel MH, Legewie S# and Tiwari VK# (2016) Identifying novel transcriptional regularors with circadian expression. Mol Cell Biol, 36:545–558 (*indicates joint contribution, #indicates joint correspondence) Link


Bastiaens P, Birtwistle MR, Blüthgen N, Bruggeman FJ, Cho KH, Cosentino C, de la Fuente A, Hoek JB, Kiyatkin A, Klamt S, Kolch W, Legewie S, Mendes P, Naka T, Santra T, Sontag E, Westerhoff HV and Kholodenko BN (2015) Silence on the relevant literature and errors in implementation. Nat Biotechnol, 33:336–339 Link

Kamenz J, Mihaljev T, Kubis A, Legewie S# and Hauf S# (2015) Robust ordering of anaphase events by adaptive thresholds and competing degradation pathways. Mol Cell, 60:446–459 (#indicates joint correspondence) Link


Casanovas G, Banerji A, D’Alessio F, Muckenthaler MU# and Legewie S# (2014) A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis. PLOS Comput Biol, 10:e1003421 (#indicates joint correspondence) Link

Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S# and Eils R# (2014) Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Sci Signal, 7:ra23 (#indicates joint correspondence) Link

Kallenberger SM, Legewie S and Eils R (2014) Applications in cancer research: Mathematical models of apoptosis. Pages 455–481 in: Computational Systems Biology (eds. Eils R & Kriete A), Academic Press, Amsterdam  Link


Blüthgen N and Legewie S (2013) Robustness of signal transduction pathways. Cell Mol Life Sci, 70:2259–2269 Link

Jeschke M, Baumgärtner S and Legewie S (2013) Determinants of cell-to-cell variability in protein kinase signaling. PLOS Comput Biol, 9:e1003357 Link


Kallenberger S and Legewie S (2012) Modeling formalisms in systems biology of apoptosis. Pages 1–32 in: Systems Biology of Apoptosis (ed. Lavrik IN), Springer, New York  Link

Schmidt-Glenewinkel H, Reinz E, Bulashevska S, Beaudouin J, Legewie S, Alonso A and Eils R (2012) Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR. FEBS Lett, 586:1179–1189 Link

Schmiedel JM, Axmann IM and Legewie S (2012) Multi-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior. PLOS One, 7:e42296 Link

Stelniec-Klotz I*, Legewie S*, Tchernitsa O, Witzel F, Klinger B, Sers C, Herzel H, Blüthgen N and Schäfer R (2012) Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS. Mol Syst Biol, 8:601 (*indicates joint contribution) Link


Kober AMM*, Legewie S*, Pforr C, Fricker N, Eils R, Krammer PH and Lavrik IN (2011) Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation. Cell Death Dis, 2:e212 (*indicates joint contribution) Link

Paulsen M*, Legewie S*, Eils R, Karaulanov E and Niehrs C (2011) Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci USA, 108:10202–10207 (*indicates joint contribution) Link

Schmidt-Glenewinkel, Hannah LS, Brors B and König R (2011) Cellular Systems Biology. Pages 295–314 in: An introduction to molecular biotechnology: Fundamentals, methods and applications (ed. Wink M), Wiley-Blackwell, Weinheim Link



Nazarenko I, Jenny M, Keil J, Gieseler C, Weisshaupt K, Sehouli J, Legewie S, Herbst L, Weichert W, Darb-Esfahani S, Dietel M, Schafer R, Ueberall F and Sers C (2010) Atypical protein kinase C ζ exhibits a proapoptotic function in ovarian cancer. Mol Cancer Res, 8:919–934 Link


Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schäfer R, Herzel H and Sers C (2009) A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts. FEBS J, 276:1024–1035 Link

Borisov N, Aksamitiene E, Kiyatkin A, Legewie S, Berkhout J, Maiwald T, Kaimachnikov NP, Timmer J, Hoek JB and Kholodenko BN (2009) Systems-level interactions between insulin–EGF networks amplify mitogenic signaling. Mol Syst Biol, 5:256 Link

Legewie S, Sers C and Herzel H (2009) Kinetic mechanisms for overexpression insensitivity and oncogene cooperation. FEBS Lett, 583:93–96 Link


Blüthgen N and Legewie S (2008) Systems analysis of MAPK signal transduction. Essays Biochem, 45:95–108 Link

Chauhan A*, Legewie S*, Westermark PO, Lorenzen S and Herzel H (2008) A mesoscale model of G1/S phase transition in liver regeneration. J Theor Biol, 252:465–473 (*indicates joint contribution) Link

Legewie S, Dienst D, Wilde A, Herzel H and Axmann IM (2008) Small RNAs establish delays and temporal thresholds in gene expression. Biophys J, 95:3232–3238 Link

Legewie S, Herzel H, Westerhoff H V and Blüthgen N (2008) Recurrent design patterns in the feedback regulation of the mammalian signalling network. Mol Syst Biol, 4:190 Link


Axmann IM, Legewie S and Herzel H (2007) A minimal circadian clock model. Genome Inform, 18:54–64 Link

Blüthgen N, Legewie S, Herzel H and Kholodenko B (2007) Mechanisms generating ultrasensitivity, bistability, and oscillations in signal transduction. Pages 282–299 in: Introduction to systems biology (ed. Choi S), Humana Press, Totowa ISBN 978-1-59745-531-2

Legewie S, Schoeberl B, Blüthgen N and Herzel H (2007) Competing docking interactions can bring about bistability in the MAPK cascade. Biophys J, 93:2279–2288 Link


Bluthgen N, Bruggeman FJ, Legewie S, Herzel H, Westerhoff H V. and Kholodenko BN (2006) Effects of sequestration on signal transduction cascades. FEBS J, 273:895–906 Link

Legewie S, Blüthgen N and Herzel H (2006) Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLOS Comput Biol, 2:e120 Link